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Effect of tongfu granules on intestinal microflora barrier function in rats with antibiotic-associated colitis LI Dan;REN Ai-min;WANG Hong;XU Shu-zhen Journal of Capital Medical University    2012, 33 (3): 315-321.   DOI: 10.3969/j.issn.1006-7795.2012.03.007 Abstract （1158）      PDF（pc） （2698KB）（6683）       Knowledge map    Save Objective To investigate the effects of Tongfu granules on intestinal microflora barrier function in rats with antibiotic-associated colitis. Tongfu granules which is a kind of Chinese traditional medicine. The present study aimed to investigate protecting effect of the medicine on impaired intestinal mucosa, and further study effects of Dahuang and Houpo which are the two main components of Tongfu granules. Methods Eighty male rats were divided into ten groups. After making the models of Lincomycin induced antibiotic-associated colitis, blood samples of rats were taken for measuring endotoxin.The colonic contents of rats were collected to culture four floras: bacillus acidi lactici, bacillus bifidus, enterococci bacillus coli. The pathological change of intestinal mucosa was observed using light microscope. Results The body weight of the model group was significantly decreased, a significant difference was shown between Houpo and Tongfu granule in weight. The endotoxin in rats of treatment group was decreased. But insignificant difference was shown among Dahuang, Houpo and Tongfu granule groups in endotoxin. There was a significant difference (P<0.05) between Tongfu granule and model group after treatment. The number of bacillus acidi lactici, bacillus bifidus, enterococci bacillus coli increased. The scores of the lesions showed a significant difference between Tongfu granule and Dahuang. Conclusion There was injury in intestinal mucosal barrier in antibiotic-associated colitis rats. Chinese Traditional medicine Tongfu granules Dahuang and Houpo had protective effects on the smalI intestinal barrier. They can decrease the endotoxin level of antibiotic-associated colitis rats. They also could recover the intestinal flora. Tongfu granule was better than Dahuang and Houpo. Related Articles | Metrics Cited: Baidu(3)

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Analysis of imaging characteristics, treatment and prognostic factors of primary abdominal cocoon LI You-guo;SONG Mao-min;BAI Ri-xing;ZHENG Jian-wei;YUAN Hui-sheng Journal of Capital Medical University    2012, 33 (1): 74-78.   DOI: 10.3969/j.issn.1006-7795.2012.01.015 Abstract （1345）      PDF（pc） （1155KB）（5785）       Knowledge map    Save Objective To investigate the imaging characteristics and prognostic factors of primary abdominal cocoon.Methods The clinical features, CT information, treatment and prognosis of patients with primary abdominal cocoon in Beijing Tiantan Hospital from January 2000 to December 2009 were retrospectively analyzed.Results All 6 patients showed an obstruction. Abdominal plain X-ray showed intestinal loop expansion of product gas and liquid gas plane in the small bowel. Abdominal CT examination showed a conglomeration of multiple small bowel loops encapsulated in a thickened capsule. Abdominal ultrasound examination showed some expansion of small bowel and 4 patients showed a small amount of ascites. Five patients had barium meal examination, all demonstrated barium slowly moved through the distal ileum, with one of the 5 patients showing stenosis in the distal ileum, another one showed complete obstruction. Laparotomy revealed that all or part of the small intestine was wrapped by a layer of dense gray tough fibrous membrane and the omentum was absent. All the patients underwent partial fiber membrane cystectomy, adhesion lysis, etc., 1 case underwent partial small bowel resection. All patients were cured.Conclusion Gastrointestinal imaging and abdominal CT examination has important diagnostic value for primary abdominal cocoon. Surgery is a safe and effective treatment. Related Articles | Metrics Cited: Baidu(2)

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Hepatotoxicity Caused by Commonly-used Chinese Medicinal Herbs and Compound Preparation Wang Xiujuan;Xu Liping;Wang Min Journal of Capital Medical University    2007, 28 (2): 220-224.   Abstract （1158）      PDF（pc） （466KB）（5753）       Knowledge map    Save The manifestations of hepatotoxicity caused by Chinese medicinal herbs are similar with ordinary liver disease. Many pathological alterations of hepatotoxicity can be seen, such as hepatocellular damage, liver disfunction, increased serum transaminase, hepatomegalia, jaundice, cholestasis, chronic hepatitis complicated with fibrosis, hepatic cirrhosis、fulminating hepatic failure, liver tumor, and etc. In most cases, the liver damage is reversible after discontinuation. The commonly-seen herbs which may cause hepatotoxicity are Huang Yao Zi(Tuber Dioscoreae Bulbiferae)、Cang Er Zi(Fructus Xanthii Sibirici)、Lei Gong Teng(Radix Tripterygum)、Ku Lian Zi(Fructus Meliae Azedarach), etc., and the compound preparations are Zhuang Gu Guan JIe Wan(The Pill for Asthritis), Ke Yin Wan(The Pill for Psoriasis), Xiao Chai Hu Tang (Xiao Bupleuri Decoction), and so on. In addition, the improper combination of Western medication and Chinese medicinal herbs may also bring about hepatotoxicity. Except the toxicity of herbs themselves, the other factors include the dosage, time, the body constitution of patients, sensitivity, seasons, and geographic regions, etc. Therefore, the medicinal herbs and their preparations should be used rationally under the guidance of the theory of traditional Chinese medicine and differentiation of symptoms, and the medical skill should be improved, which are the effective measures for avoiding hepatotoxicity. Related Articles | Metrics

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Lipodystrophic syndromes ZHAO Xiangfu, ZHUANG Xiaoming Journal of Capital Medical University    2013, 34 (2): 315-323.   DOI: 10.3969/j.issn.1006-7795.2013.02.029 Abstract （3446）      PDF（pc） （3258KB）（5097）       Knowledge map    Save The lipodystrophic syndromes are a heterogeneous group of congenital or acquired disorders characterized by either complete or partial lack of adipose tissue,which may occur in conjunction with pathological accumulation of fat in other distinct regions of the body. Patients with lipodystrophy suffer from numerous metabolic complications, such as severe insulin resistance, impaired glucose tolerance, diabetes mellitus, severe hyperlipidemia, progressive liver disease, and increased metabolic rate, serum leptin concentration can be low, indicating the importance of adipose tissue as an active endocrine organ. Not only does the total amount but also the appropriate distribution of fat deposits contribute to the metabolic state. Recent genetic and molecular research has improved our understanding of the mechanisms underlying lipodystrophy. Circulating levels of hormones secreted by adipose tissue, such as leptin and adiponectin, are greatly reduced in distinct subsets of patients with lipodystrophy, rationalizing the use of such hormones or agents that increase their circulating levels, such as peroxisome proliferator-activated receptor gamma(PPARγ) agonists, in a subset of patients with lipodystrophy. Other novel therapeutic approaches, including the use of growth hormone(GH) and GH-releasing factors, are also being studied as potential additions to the therapeutic armamentarium. Insights from recent research efforts and clinical trials could potentially revolutionize the treatment of this difficult-to-treat condition. Reference | Related Articles | Metrics Cited: Baidu(2)

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Journal of Capital Medical University    2002, 23 (3): 277-280.   Abstract （717）      PDF（pc） （436KB）（4168）       Knowledge map    Save Related Articles | Metrics

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Comparison of Three Imaging Methods in the Early Diagnosis of the Breast Cancer XU Guang-zhong;LI Kai;FENG Guo-sheng Journal of Capital Medical University    2009, 30 (3): 293-297.   DOI: 10.3785/j.issn.1006-7795.2009.03.008 Abstract （1410）      PDF（pc） （1061KB）（3916）       Knowledge map    Save Objective To study the value of 3 different imaging methods in the early diagnosis of breast cancer and differential diagnosis of benign versus malignant nature of breast tumors. Methods Three hundred and ten patients with breast disease seen from 2004 to 2008 were randomly selected in this study. Diagnosis of all the patients were confirmed by means of surgery and pathological examinations, and all the patients were examined by high frequency ultrasound and mammography before operation. Using the results of pathologic examination as the gold standard, the authors compared the result of high frequency ultrasound with that of mammography, and compared the result of any one method with the combined results of the other two. The authors also reviewed the results of 20 patients with breast carcinoma in whom magnetic resonance imaging was additionally applied to see its value in the diagnosis on breast carcinoma. Results The rate of consistency of the ultrasound on diagnosing breast carcinoma was 85 percent, while that of breast benign disease was 89.5 percent. The rate of consistency of the mammography on diagnosing breast carcinoma was 86 percent, while that of breast benign disease was 83.8 percent. The ultrasound could identify 85 of the 100 cases with breast carcinoma. While the mammography could make diagnosis for 86 of 100 patients with breast carcinoma. The combination of the both could make diagnosis for 95 of the 100 patients with breast carcinoma. In the 20 patients with breast carcinoma who were examined by magnetic resonance imaging, the accordance rate for diagnosis with the combination of the three was 100 percent. Though no significant difference in the diagnostic accuracy was found between the ultrasound and the mammography, the combination of the both could greatly elevate the diagnosis accuracy. Conclusion 1 The combination of mammography and high frequency ultrasound can be the first choice of methods to diagnose breast carcinoma in the early stage; 2 MRI can be a good supplement to mammography and high frequency ultrasound; 3 Mammography has great importance in diagnosing breast precancerosis-breast atypical hyperplasia, it is a much better method to diagnose breast atypical hyperplasia. Related Articles | Metrics Cited: Baidu(21)

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Analysis of LI Ping;WANG Ju-sheng;ZHAO Jing-xia;WANG Ping;LIU Xin;ZHANG Guang-zhong;ZHOU Dong-mei Journal of Capital Medical University    2009, 30 (4): 413-417.   DOI: 10.3785/j.issn.1006-7795.2009.04.002 Abstract （1451）      PDF（pc） （1160KB）（3852）       Knowledge map    Save Psoriasis is one of the most common and gene-related human skin diseases. Traditional Chinese medical therapy has curative effect with fewer side effects, so the investigation of the rules of TCM differentiation and pharmacological treatment in psoriasis would provide us a new approach to improve its clinical practice. By document analysis, we proposed a hypothesis that the pathogenesis of psoriasis-'toxin accumulation in blood' means the disease happened in blood and its characteristic was 'toxin coming from excessive heat’. In addition, we elucidated the meaning of 'toxin accumulation in blood’ in the view of modern medicine, which might develop the TCM theory of 'treating psoriasis by modulating blood’. Related Articles | Metrics

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Correlation between neurological deficits scores and infarct volume in focal cerebral ischemia in rats WANG Rongliang, LIU Xiaomeng, ZHANG Ying, JI Xunming, LUO Yumin Journal of Capital Medical University    2013, 34 (1): 69-74.   DOI: 10.3969/j.issn.1006-7795.2013.01.013 Abstract （1291）      PDF（pc） （3702KB）（3764）       Knowledge map    Save Objective To investigate the correlation between three scores of neurological deficits and infarct volume of middle cerebral artery occlusion (MCAO) model in rats. Methods A total of 20 Sprague-Dawley (SD) rats were randomly divided into five groups. MCAO models were induced. At five different time points (24 h, 3 d, 7 d, 14 d and 30 d after reperfusion), three grading methods (Longa test, Forelimb Placing test and Ludmila Belayev test) were used to evaluate neurological functions of rats. Then, the volume of infarction was calculated after taking the brain for HE staining. The correlations between neurological function scores and brain infarction volumes were analyzed by ANOVA and correlation.Results From 24 hours to 30 days after reperfusion, the scores of neurological deficits and the volume of infarction were decreased. There were significant differences in the scores of forelimb placing test and Ludmila Belayev test between 7 and 30 days after reperfusing (P<0.05). But the differences of infarction volume at different time points were insignificant (P>0.05). In terms of the correlation between the Ludmila Belayev score and infarction volume, there exists the obvious statistical significance at 3 (P<0.01) and 30 days (P<0.05). Conclusion For the MCAO model of rats, the Ludmila Belayev test can be used to evaluate the extent of injury after cerebral infarction at 3 and 30 days after reperfusion. Reference | Related Articles | Metrics Cited: Baidu(14)

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Comparison between Different Methods to Extract Mitochondria and Its Effects on Mitochondria Content and Activity WU Yuan, DONG Ling-yue, AN Wei, AN Yun-qing Journal of Capital Medical University    2010, 31 (2): 241-244.   DOI: 10.3969/j.issn.1006-7795.2010.02.020 Abstract （1935）      PDF（pc） （419KB）（3564）       Knowledge map    Save Objective To compare different methods for extracting mitochondria and its effects on mitochondria content and their activity. Methods Pulilai kit, sucrose gradient centrifugation and Pierce mitochondria extraction kit were used to extract mitochondria and quantify their concentration, activity and contamination. Results Pulilai kit yielded higher concentration of mitochondria proteins than two other methods(P<0.05) when the same amount of cells were used. Western blotting was used to evaluate the amount of cytosolic protein contaminant and mitochondria protein cytochrome c from mitochondria fraction. The result suggests that using Pulilai kit can yield lower concentration cytosolic protein contaminant and higher concentration of cytochrome c from mitochondria fraction than the other two methods. At the same time, ATP content of mitochondria extracted by the method of Pulilai kit was the greatest. Conclusion Pulilai kit is better than sucrose gradient centrifugation and Pierce mitochondria extraction kit for mitochondria extraction. Related Articles | Metrics Cited: Baidu(8)

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Evidence-based Medicine Approach and TCM Therapeutic Evaluation Liu Jianping Journal of Capital Medical University    2007, 28 (2): 212-215.   Abstract （903）      PDF（pc） （477KB）（3447）       Knowledge map    Save WHO promotes evidence-based traditional medicine. Methodological issues limit evaluation of therapeutic effect of TCM. Current methods for evaluation do not properly reflect the humanity characteristics and holistic approach and differentiation of syndrome and prescription. TCM therapeutics is a complex intervention, and there is a limitation of methodology by only randomized, double-blind, placebo-controlled trials as it doesn't comply with bio-psycho-social-environmental and spiritual model for modern medicine. To fairly evaluate TCM therapeutic, we need to combine both quantitative and qualitative methods together, so as to create modality and methodology for TCM differentiation of syndrome and treatment. Related Articles | Metrics Cited: Baidu(24)

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Research progress of psoriasis-like models DI Ting-ting;ZHAO Jing-xia;LI Ping Journal of Capital Medical University    2012, 33 (2): 275-279.   DOI: 10.3969/j.issn.1006-7795.2012.02.030 Abstract （1190）      PDF（pc） （1015KB）（3290）       Knowledge map    Save Lack of the naturally occurred psoriasis animal models once made the researches on human psoriasis phenotype and pathogenesis stagnated in last several years. But with the increasing understanding of psoriasis mechanism, a series of models has been explored at organic, cellular and molecular levels. We evaluated the current psoriasis models and analyze theirs advantages and limitations, to provide reference for psoriasis studying, drug screening and treatment. Related Articles | Metrics Cited: Baidu(2)

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Journal of Capital Medical University    2004, 25 (4): 557-559.   Abstract （719）      PDF（pc） （142KB）（3238）       Knowledge map    Save Related Articles | Metrics

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B cell receptor signaling pathway and its therapeutic implications in B-cell lymphoma Wang Jingwen, Li Zhenjun, Lyu Liangcheng, Yao Xiaoyu, Ding Ning Journal of Capital Medical University    2025, 46 (3): 436-441.   DOI: 10.3969/j.issn.1006-7795.2025.03.006 Abstract （974）      PDF（pc） （464KB）（3117）       Knowledge map    Save B-cell lymphomas account for 70%－80% of non-Hodgkin lymphomas（NHL） and exhibit significant heterogeneity in genetic profiles, phenotypic characteristics, and clinical manifestations, posing substantial challenges for clinical management. The B-cell receptor (BCR) is a transmembrane receptor on the surface of B cells that plays a central regulatory role in B-cell development, activation, and adaptive immune responses. As a core mechanism driving malignant transformation in various B-cell malignancies, aberrant activation of the BCR signaling pathway, plays a pivotal role in B lymphoma pathogenesis. Dysregulated BCR signaling not only promotes tumor cell proliferation, survival, and anti-apoptotic capacity but also accelerates malignant progression. Consequently, researchers are vigorously exploring therapeutic strategies targeting BCR and its downstream pathways, including inhibitors of Bruton's tyrosine kinase (BTK) and PI3K, as well as direct BCR-targeted approaches. The central role of BCR signaling in lymphoma pathogenesis and treatment underscores its potential as a critical focus for future therapeutic development, offering new directions and hope for improved clinical outcomes. Reference | Related Articles | Metrics

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Research progress of effects and mechanisms of paeony and total glucosides of paeony in treatment of immune-associated dermatoses Yang Yang, Chen Ruixuan, Min Li, Ma Zhijie, Mei Xueling, Journal of Capital Medical University    2024, 45 (1): 1-7.   DOI: 10. 3969/ j. issn. 1006-7795. 2024. 01. 001 Abstract （822）      PDF（pc） （1315KB）（2967）       Knowledge map    Save Pharmacological studies have shown that white paeony has anti-inflammatory,immunomodulatory,hepatoprotective,and analgesic effects. In clinical practice, paeony and total glucosides of paeony are often used to treat autoimmune diseases. As the anti-inflammatory, immune-modulating and anti-oxidizing mechanisms of paeony and total glucosides of paeony are gradually understood,their clinical applications in immune-related and inflammatory skin diseases have been continuously expanded. The mechanisms such as anti-oxidation play an important role in enhancing efficacy,attenuating toxicity,and reducing disease recurrence rates. This article reviews the research progresses on the effects and mechanisms of paeony and total glucosides of paeony in the treatment of immune-related and inflammatory skin diseases, to provide a basis for in-depth research. Reference | Related Articles | Metrics

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Professor Fa-zi Cong's Clinical Experience in Treatment of Luteal Phase Defect-induced Infertilitas Feminis by Menstrual Cycling Therapy Yang Hong Journal of Capital Medical University    2008, 29 (4): 528-530.   Abstract （878）      PDF（pc） （171KB）（2954）       Knowledge map    Save Professor Fa-zi Cong has worked as a clinician of Traditional Chinese Medicine(TCM) for more than fifty years and made great achievement in the treatment of luteal phase defect(LPD)-induced infertilitas feminis.In this manuscript,we collected Professor Cong's idea that the LPD-induced infertilitas feminis could be healed by menstrual cycling therapy according to the TCM differentiation of symptoms and diseases.During regulating menstrual cycle of patient by the TCM differentiation of Chinese herb usage,the following key points should be referred:the critical time of menstrual cycle,the basal body temperature(BBT) curve,and the adjustment on meals. Related Articles | Metrics Cited: Baidu(2)

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Evaluation of Middle Cerebral Artery Occlusion Induced Focal Cerebral Ischemia Model in Mice YU Pei-lan, SUI Lei-ming, HAN Song, ZHAO Huan-ying, JIANG Jun, LI Jun-fa Journal of Capital Medical University    2010, 31 (5): 586-590.   DOI: 10.3969/j.issn.1006-7795.2010.05.014 Abstract （1797）      PDF（pc） （362KB）（2919）       Knowledge map    Save Objective To study the success rate and reliability of middle cerebral artery occlusion(MCAO) model by objective and reliable neurological score, infarct volume, and edema rate. Methods Cerebral ischemia model of MCAO was established in mouse using the suture method. Infarct volume, edema rate and behavioral performance was evaluated by 2,3,5-triphenyltetrazolium chloride(TTC) staining and neurological score. Results MCAO could induce obvious focal cerebral ischemia by TTC staining and the success rate of this model was about 90.8%. Besides, MCAO could induce three types of cerebral ischemia: cortical, hippocampal and thalamic ischemia. And the predominant type is cortical ischemia. MCAO-induced cerebral ischemia could significantly increase the neurological score compared with the sham group. The procedure for infarct volume evaluation of the MCAO model was accurate and stable; infarct volume was about 35% of entire brain volume. Conclusion Cerebral ischemia model of MCAO was established in mice successfully(90.8%). The evaluation of neurological deficit and infarct volume was technically reliable. Related Articles | Metrics Cited: Baidu(7)

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Clinical Characteristics of Aspirin Resistance in Patients with Cardiovascular Diseases Zhu Zhengyan;Hu Dayi;Shi Xubo;Wang Chunbo;Zhu Jingyan;Yang Jingang;Li Tianchang Journal of Capital Medical University    2005, 26 (2): 128-131.   Abstract （1002）      PDF（pc） （403KB）（2855）       Knowledge map    Save Objective The study was designed to investigate the clinical characteristics of aspirin resistance in patients with cardiovascular diseases.Methods 326 patients with stable cardiovascular diseases were evaluated for aspirin resistance with idetection of optical platelet aggregation induced by arachidonic acid(AA) and adenosine diphosphate(ADP). Aspirin resistance was defined as an average aggregation of over 20% with 0.5 mmol/L AAand over 70% with 10 μmol/L ADP. Aspirin semiresistance met one, but not both of the above criteria. Results 4.9% of the patients were aspirin resistant and 27.6% were aspirin-semiresistant. The clinical characteristics of aspirin resistant patients compared with aspirin sensitive patients were: 1) most of the aspirin-resistant patients were senile; 2) female patients were more frequent than male; 3) patients with diabetes were dominant in number; 4) it had nothing to do with hypertension, hyperlipodemia, red blood cell count, hemoglobin and platelet count; 5) it was relatively rare in smoking population. Conclusion The incidence of aspirin resistance is similar to other studies, in addition to aging and female gender, diabetes is also a risk factor in aspirin resistance. Related Articles | Metrics

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Research progress in the mechanism and prediction of suicide attempt in patients with depression Ren Yanping, Wu Han, Wang Wen, Jin Wenqing, Li Rena Journal of Capital Medical University    2024, 45 (1): 88-96.   DOI: 10. 3969/ j. issn. 1006-7795. 2024. 01. 015 Abstract （630）      PDF（pc） （556KB）（2843）       Knowledge map    Save Suicide is the act of individuals intentionally or voluntarily taking various means to end their lives. The global annual suicide mortality rate is approximately 16/100 000,which means approximately 703 000 people die from suicide every year,making it the leading cause of death. Suicide often occurs in patients among which mental illness, among which the most common is depression. Studying the mechanism of suicidal behavior in depression can provide important data support for developing measares to prevent  from suicidal ideation and suicidal behavior. The relevant factors for suicidal behavior include social,psychological,and biological factors. The article reviewed the advances related to suicidal behavior in magnetic resonance imaging,neurocognitive research,machine learning,ecological momentary assessment and digital phenotype,in order to provide reference for the development of early identification indicators for suicide risk. Reference | Related Articles | Metrics

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Progress on the injury and repair mechanism of renal tubular epithelial cells in the transition of acute kidney injury to chronic kidney disease Chen Xiaomei, Ma Yuanyuan, Nie Jing, Zhu Fengxin Journal of Capital Medical University    2022, 43 (5): 720-727.   DOI: 10.3969/j.issn.1006-7795.2022.05.009 Abstract （733）      PDF（pc） （1051KB）（2814）       Knowledge map    Save Acute kidney injury (AKI) is a clinical syndrome caused by various factors and characterized by renal function declines sharply in a short period of time. AKI, an independent risk factor of chronic kidney disease (CKD) and end-stage renal disease, is associated with high levels of morbidity and mortality. Currently, the treatments for AKI and the prevention of the transition of AKI to CKD are very limited. Therefore, it is essential to explore the mechanism of AKI to CKD. Renal tubular epithelial cells (RTECs) are the major cells of the kidney and are vulnerable to various biological stresses, such as ischemia, hypoxia and toxins.RTECs are also key inflammatory and fibrogenic cells that drive the progression from acute to chronic kidney disease. In view of the central role of RTECs, this review will focus on the maladaptive repair mechanisms of RTECs in the transition of AKI to CKD, providing novel targets and new strategies for effective treatment. Reference | Related Articles | Metrics

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Application research hotspot of traditional Chinese medicine informatics Gao Man, Li Haiyan Journal of Capital Medical University    2022, 43 (4): 592-599.   DOI: 10.3969/j.issn.1006-7795.2022.04.013 Abstract （589）      PDF（pc） （1014KB）（2707）       Knowledge map    Save This paper summarized the popular applications of traditional Chinese medicine(TCM) informatics research to provide useful references for researchers, which include TCM clinical data mining and utilization, TCM intelligent diagnosis and treatment equipment research, Chinese medicine information research, discipline knowledge service based on TCM ancient and modern literature information, and TCM evaluation research based on big data. Reference | Related Articles | Metrics