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Brief report on stroke prevention and treatment in China,2024 Stroke Prevention Project, National Health Commission, Ji Xunming Journal of Capital Medical University    2025, 46 (6): 947-960.   DOI: 10.3969/j.issn.1006-7795.2025.06.001 Abstract （1883）      PDF（pc） （5215KB）（1027）       Knowledge map    Save lthough China has a slight decline in stroke incidence in recent years, it still seems to be the leading health threat to Chinese citizens. China continues to bear a heavy stroke burden which has distinct epidemiological characteristics, while major risk factors remain prevalent and poorly controlled. Markedly, the government is putting effort into advancing the stroke prevention and treatment system, meanwhile, continuously funding cerebrovascular disease research, and driving steady improvements in diagnosis and treatment capabilities. However,  stroke prevention and control work in China still faces considerable challenges. This report systematically reviews the current state of stroke prevention and treatment in China during 2023 from five perspectives: epidemiological characteristics, risk factors, diagnostic and therapeutic advances, prevention system development and stroke center construction, aiming to provide references for clinical practice. Reference | Related Articles | Metrics

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Association between lactobacillus species and bacterial vaginosis associated bacteria in non-pregnant women CHEN Jianing, LV Zhi, SU Jianrong, KANG Xixiong Journal of Capital Medical University    2013, 34 (4): 535-539.   DOI: 10.3969/j.issn.1006-7795.2013.04.011 Abstract （1186）      PDF（pc） （1058KB）（824）       Knowledge map    Save Objective To evaluate the association between popular lactobacillus species and bacterial vaginosis(BV) associated bacteria in vaginal flora. Methods Vaginal fluid samples were taken from 170 women, classified as BV(n=86) or non-BV(n=84) using the Amsel criteria and Nugent score system. Genomic DNA extracted from these samples was analyzed for bacterial sequences of three Lactobacillus species(L. crispatus, L. jensenii and L. iners) and five BV associated bacteria(G.vaginalis, A. vaginae, prevotella sp, megasphaera sp and leptotrichia sp) by 16S rRNA PCR. Results The prevalence of Lactobacillus species was significantly higher in the non-BV group than in the BV group, the BV associated bacteria vice versa. Women without L. jensenii were significantly more likely to have G. vaginalis, A. vaginae and leptotrichia sp, without L. iners more likely to have G. vaginalis, without L. crispatus likely to have prevotella sp. Five BV associated bacteria coexisted with each other except that there was no significant association between megasphaera sp and G. vaginalis. Conclusion Not only normal vaginal flora, BV vaginal flora was complicated also because many different BV associated bacteria coexisted. The absence of L. jensenii or L. iners may influence the prevalence of BV associated bacteria. Reference | Related Articles | Metrics

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Research progress of functional dyspepsia in Chinese medicine Zhang Shengsheng, Li Xiaoling Journal of Capital Medical University    2015, 36 (4): 649-653.   DOI: 10.3969/j.issn.1006-7795.2015.04.027 Abstract （402）      PDF（pc） （991KB）（264）       Knowledge map    Save Functional dyspepsia is a most common functional gastrointestinal disease affecting people's daily life. The etiology and pathogenesis of FD has not been fully elucidated. Western medicine diagnostic typing remains controversial while Chinese medicine treatment of FD shows great advantage. Reference | Related Articles | Metrics Cited: Baidu(10)

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Progression in autoimmune encephalitis after herpes simplex virus infection Chi Bowen, Wang Jiawei Journal of Capital Medical University    2021, 42 (3): 341-346.   DOI: 10.3969/j.issn.1006-7795.2021.03.001 Abstract （556）      PDF（pc） （2938KB）（370）       Knowledge map    Save Autoimmune encephalitis caused by herpes simplex virus encephalitis has received increasing attention, the pathogenesis of which may be related to the immune response caused by the release of antigens after the herpes simplex virus infecting neurons. This secondary autoimmune encephalitis has various clinical manifestations, which are easily confused with recurrent herpes simplex virus encephalitis. The delayed treatment may lead to severe neurological deficits and poor prognosis. The detection of autoimmune encephalitis related antibodies in cerebrospinal fluid and serum is helpful for diagnosis. Immunotherapy is effective for autoimmune encephalitis secondary to herpes simplex virus encephalitis. This article reviews the development history, pathogenesis, clinical manifestations, auxiliary examinations, diagnosis, and treatment procedures of autoimmune encephalitis after herpes simplex virus infection. Reference | Related Articles | Metrics

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Journal of Capital Medical University    2013, 34 (5): 786-786.   Abstract （439）      PDF（pc） （1172KB）（458）       Knowledge map    Save Related Articles | Metrics

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Journal of Capital Medical University    2006, 27 (5): 0-0.   Abstract （509）      PDF（pc） （335KB）（251）       Knowledge map    Save Related Articles | Metrics

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Progress on the injury and repair mechanism of renal tubular epithelial cells in the transition of acute kidney injury to chronic kidney disease Chen Xiaomei, Ma Yuanyuan, Nie Jing, Zhu Fengxin Journal of Capital Medical University    2022, 43 (5): 720-727.   DOI: 10.3969/j.issn.1006-7795.2022.05.009 Abstract （490）      PDF（pc） （1051KB）（283）       Knowledge map    Save Acute kidney injury (AKI) is a clinical syndrome caused by various factors and characterized by renal function declines sharply in a short period of time. AKI, an independent risk factor of chronic kidney disease (CKD) and end-stage renal disease, is associated with high levels of morbidity and mortality. Currently, the treatments for AKI and the prevention of the transition of AKI to CKD are very limited. Therefore, it is essential to explore the mechanism of AKI to CKD. Renal tubular epithelial cells (RTECs) are the major cells of the kidney and are vulnerable to various biological stresses, such as ischemia, hypoxia and toxins.RTECs are also key inflammatory and fibrogenic cells that drive the progression from acute to chronic kidney disease. In view of the central role of RTECs, this review will focus on the maladaptive repair mechanisms of RTECs in the transition of AKI to CKD, providing novel targets and new strategies for effective treatment. Reference | Related Articles | Metrics

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Journal of Capital Medical University    2025, 46 (6): 0-0.   Abstract （37）      PDF（pc） （4152KB）（29）       Knowledge map    Save Related Articles | Metrics

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Damage of hyperhomocysteinemia on generation oxidation in smooth muscle cells LI Yan;ZHAGNG Chun-lai;LU Feng;WANG Li-zhong;JIANG Yu-fen Journal of Capital Medical University    2012, 33 (2): 251-254.   DOI: 10.3969/j.issn.1006-7795.2012.02.024 Abstract （1013）      PDF（pc） （1013KB）（488）       Knowledge map    Save Objective Many recent studies have indicated that homocysteine(Hcy) is an important and independent risk factor for atherosclerosis(AS). This study aimed to test the effects of Hcy on the vascular smooth muscle cells in rabbits' carotid artery by feeding New Zealand white rabbits with high concentration of Hcy. Methods The carotid artery was separated after feeding with high methionine foods for three months. The vascular smooth muscle cells(VSMCs) in rabbits' carotid artery were separated, cultured and passaged. The intracellular superoxide dismutase(SOD) activity was tested using the xanthine oxidation.The intracellular activity of catalase(CAT) was measured by visible colorimetric method. Results The pathomorphological change of the separated rabbit carotid artery with methionine diet group was compared with control group under optical microscope. I: Intima; M: Medial. The CAT and SOD activity of rabbit carotid artery smooth muscle cells increase under Hcy diet group. Conclusion High Hcy accelerated VMSC proliferation, and may increase peroxidizine damages of VMSCs within the scope of certain dose, eventually accelerate the process of AS. Related Articles | Metrics Cited: Baidu(9)

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, Journal of Capital Medical University    2017, 38 (1): 113-115.   DOI: 10.3969/j.issn.1006-7795.2017.01.023 Abstract （192）      PDF（pc） （2665KB）（568）       Knowledge map    Save Reference | Related Articles | Metrics

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Progresses in Studies on Immune Reconstitution Inflammatory Syndrome in HIV/AIDS Patients WU Wei;HUANG Shi-jing;WANG Jie Journal of Capital Medical University    2009, 30 (5): 710-713.   DOI: 10.3969/j.issn.1006-7795.2009.05.029 Abstract （916）      PDF（pc） （968KB）（499）       Knowledge map    Save Immune reconstitution inflammatory syndrome (IRIS) occurred in the process of immune reconstitution disease after highly active antiretroviral therapy. In this paper, the concept, diagnostic criteria, clinical manifestations and treatment of IRIS were reviewed. It is important to improve diagnosis and differentiation of the IRIS and reduce delays. One of the characteristics of immune reconstitution is restoration of immune response to opportunistic infections . Therefore, unless there is a threat to patient's life or a risk that may lead to a very high rate of disability, the highly active antiretroviral therapy should be continued. Related Articles | Metrics

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Flow cytometry for assessing circulating platelet activation and platelet-leukocyte adhesion Cui Wei, Liu Sa, Dong Lei, Yuan Hui, Yang Ping, Wu Yina, Li Yulin Journal of Capital Medical University    2015, 36 (3): 414-419.   DOI: 10.3969/j.issn.1006-7795.2015.03.015 Abstract （430）      PDF（pc） （1728KB）（194）       Knowledge map    Save Objective To assess the circulating platelet activation and platelet leukocyte adhesion by flow cytometry and lay the foundation for the clinical development of platelet associated diseases. Methods The sodium citrate anti-coagulation blood was collected from 50 cases of healthy volunteers, using CD61/PAC-1/CD62P to detect platelet activation; analysis the percentage of early activation (PAC-1+CD62P-) and late activation (PAC-1+CD62P+). Moreover, the different time points, such as 0 min, 5 min, 10 min, 15 min, 20 min, 30 min, and 60 min were detected the platelet activation. Via CD61/CD3/CD19/CD11b/CD14/CD45 detected platelet activation, and analyzed the percentages of platelet leukocyte adhesion (CD45+CD61+), platelet-T lymphocyte adhesion (CD3+CD61+), platelet-B lymphocyte adhesion (CD19+CD61+), platelet monocyte adhesion (CD14+CD61+), platelet-neutrophil adhesion(CD45low+CD11b+ CD61+). Results The time point of 15 minutes was detected to establish the reference range for healthy human platelet activation : the percentage of early activation was 3.75 (1.00-9.80) %, late activation was 0.10 (0.00-0.10) %. Detected the percentages of platelet leukocyte adhesion, platelet-T lymphocyte adhesion, platelet-B lymphocyte adhesion, platelet-monocyte adhesion and platelet-neutrophil adhesion showed platelet-monocyte adhesion was the highest proportion (10.75 ± 3.23)%. ConclusionStorage time of blood samples should not exceed 15 min to detect platelet activation. Platelet-monocyte adhesion was the key role in platelet activation analysis. Establishment the fast, stable, accurate evaluation method of platelet activation is important. Reference | Related Articles | Metrics

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Prevalence of female sexual dysfunction and the relationship between climacteric symptoms and female sexual dysfunction in Chinese women with menopause transition stage and postmenopausal stage Ju Rui, Ruan Xiangyan, Xu Xin, Yang Yu, Zhang Luping, Qin Shuang, Wang Binhong, Dou Zhuli, Alfred O. Mueck Journal of Capital Medical University    2020, 41 (4): 503-507.   DOI: 10.3969/j.issn.1006-7795.2020.04.001 Abstract （338）      PDF（pc） （1184KB）（708）       Knowledge map    Save Objective To investigate the effects of climacteric symptoms on female sexual dysfunction(FSD) at different reproductive aging stages. Methods A cross-sectional study including 180 cases was conducted among women over 40 years old in the Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China, from Jun. 2019 to Oct. 2019. According to the 2011 stages of the Reproductive Ageing Workshop (STRAW+10), the subjects were divided into four groups:early menopausal transition stage (group A), late menopausal transition stage (group B), early postmenopausal stage (group C), and late postmenopausal stage (group D). Female climacteric symptoms were evaluated by Modified Kupperman Index (KMI), and FSD was evaluated by Female Sexual Function Index (FSFI). Results With the increase of stages of the reproductive aging, the median age of the subjects increased from 45.5 years to 57.0 years, the median years of cohabitation with their partners increased from 20 years to 23.5 years, the median time of sexual frequency increased from 7 days to 15 days, and the median KMI increased from 9.5 to 15 days (P<0.05). With the increase of stages of the reproductive aging, the prevalence of FSD and sexual desire disorder, sexual arousal disorder, vaginal lubrication disorder, orgasm disorder, sexual satisfaction disorder, and vaginal pain were significantly increased (P<0.05). The prevalence of FSD and sexual desire disorder, sexual arousal disorder, vaginal lubrication disorder, orgasm disorder, sexual satisfaction disorder, and vaginal pain increased with the severity of menopausal symptoms (P<0.05). Conclusion With advanced stage of reproductive aging, FSD was prevalent significantly. The prevalence of FSD was higher in women with menopausal symptoms. The more severe the menopausal symptoms were, the higher the prevalence of FSD was. Climacteric symptoms and their severity are important factors affecting the occurrence of FSD in women over 40 years old. Climacteric symptoms should be actively treated to improve the quality of life of women. Reference | Related Articles | Metrics

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Antioxidant activity of lycopene-curcumin combination in mice with acute ethanol oxidative damage Gao Lifang, Gao Wen Journal of Capital Medical University    2021, 42 (1): 89-93.   DOI: 10.3969/j.issn.1006-7795.2021.01.015 Abstract （256）      PDF（pc） （1300KB）（77）       Knowledge map    Save Objective To evaluate the antioxidant effect of lycopene combined with curcumin on mice with acute alcoholism. Methods Healthy male Kunming mice were divided into 5 groups according to the weight, respectively for the blank control group, model control group, the low, medium and high three level doses subjects’ intervention group (100, 200, 600 mg/kg). The mice were given subjects through gavage administration for 30 consecutive days. On the 31st day of the experiment, the model control group and three level groups were administrated 50% anhydrous ethanol (12 mL/kg) by gavage after a 16 h overnight fasting, and the blank group was not processed. Blood was collected from the inner canthus of mice after 6 h. Those indexes were determined including the total superoxide dismutase (T-SOD) activity, protein carbonyl (PC), reduced glutathione (GSH), glutathione peroxidase activities (GSH-Px), malondialdehyde (MDA) and in blood samples of mice. Results The activities of SOD and GSH-Px, content of GSH in the high-dose group mice were higher than those in the model control group (P<0.05), and the PC content of mice in the high-dose group was lower than that in the model control group (P<0.05). Conclusion The combined application of lycopene and curcumin has potential antioxidant effects. Pretreatment with the combinations of lycopene and curcumin effectively attenuated the oxidative damage caused by acute alcoholic injury mice. Reference | Related Articles | Metrics

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Journal of Capital Medical University    2021, 42 (1): 164-166.   DOI: 10.3969/j.issn.1006-7795.2021.01.028 Abstract （146）      PDF（pc） （5479KB）（127）       Knowledge map    Save Reference | Related Articles | Metrics

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Research for the Reference Ranges of Five Essential Elements in the Serum of Healthy People between 17 and 30 Years of Age in Beijing YU Hui-yan, BI Xiao-yu, ZHAO Rui, QI Na Journal of Capital Medical University    2010, 31 (5): 642-644.   DOI: 10.3969/j.issn.1006-7795.2010.05.025 Abstract （1261）      PDF（pc） （170KB）（312）       Knowledge map    Save Objective Reference ranges of levels of five essential elements (copper, zinc, iron, calcium and magnesium) in serum of 300 healthy people between 17 and 30 years of age in Beijing were studied to provide useful data for the clinical diagnosis.Methods Based on the method of atomic absorption spectrometry, the authors tested the contents of the five elements in serum, and calculated the distribution differences of these five elements with sex and age. Results The distribution of the contents of these elements was Gaussian distribution. The levels of iron and calcium in serums between male and female had a significant difference（P＜0.05）, and the level of calcium in serum had a significant difference（P＜0.01）. Conclusion The content of iron in serum of male was higher than that of the female healthy adults in Beijing. On the contrary, the content of calcium of female was higher than that of the male. The content of calcium in serum decreased with aging. Related Articles | Metrics Cited: Baidu(5)

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Correlation between Behavior and Endocrine Changes in Children with Simple Obesity Liu Chunling;Wang Yuqin;Wang Lihong;Hu Liangping;Shang Jianwen Journal of Capital Medical University    1998, 19 (1): 37-40.   Abstract （583）      PDF（pc） （1192KB）（205）       Knowledge map    Save The aim of present study is to investigate the mechanism of simple obesity in childhood from the neuropsychology and neuroendocrinology points of view. The child behavior checklist(CBCL)and plasma concentrations of several hormones were measured in 65 children with simple obesity, whose body weight was more than 20% heavier than standard weight. 55 healthy children were taken as normal control in the study. The results showed that obese children had behavior deficit manifested by lower ability of social communication(P<0.05)and difficulty of behavioral problem(P<0.001). Abnormality of endocrine metabolism was found in obese children, showing an increase of plasma level of insulin and a decrease of growth hormone and prolactin. Their behavioral deficit and endocrine changes were related to sex and the degree of obesity. The behavioral problem in obese children was correlated to their endocrine metabolism with r=0.477(P<0.05). The correlation mainly existed between social communication and epinephrine or prolactin. The results demonstrate that children with simple obesity have, to various extent, neuropsychological deficit and abnormal endocrine metabolism. Related Articles | Metrics

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Effect of Shexiangbaoxin pills on expression of renal angiotensin Ⅱ receptor subtypes in rats with heart failure LIU Fei;LI Yan-fang;CAO Fang-fang;ZHANG Ling-ji;BAI Xue-yuan;LV Yang Journal of Capital Medical University    2012, 33 (1): 99-102.   DOI: 10.3969/j.issn.1006-7795.2012.01.020 Abstract （1049）      PDF（pc） （1037KB）（469）       Knowledge map    Save Objective To explore the effect of Shexiangbaoxin pills (SXBXP) on expression of renal angiotensin Ⅱ receptor(ATR) subtypes in rats with heart failure.Methods Eighty male Wistar rats were randomly divided into control group (group A, n=10) and sham operation group (group B, n=10). The heart failure model was established successfully in 35 of the rest 60 male Wistar rats. The 35 heart failure model rats were randomly divided into four group: heart failure model group (group C, n=9), medicine control group (group D, n=8), small dose of SXBXP group (group E, n=9) and large dose of SXBXP group (group F, n=9). The mRNA levels of ATR subtypes of renal cortex were measured by reverse transcription polymerase chain reaction (RT-PCR) in each group. Results Compared with group A, expression of AT1R and AT1R showed no significant difference in group B(P>0.05), compared with group B, expression of AT1R was increased significantly in group C(P<0.05), expression of AT1R was decreased significantly in group C(P<0.01). Compared with group C, expression of AT1R was decreased significantly in group D, E and F(P<0.05), expression of AT1R was increased significantly in group D, E and F(P<0.01). Compared with group E, expression of AT1R was decreased significantly in group F(P<0.05). Conclusion SXBXP regulated the expression of renal ATR subtypes, including the downregulation of AT1R and the upregulation of AT1R in rats with heart failure, and it is also effective to protect renal function and improve heart failure, especially large dose of SXBXP. Related Articles | Metrics

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Determination of limonene in volatile oil from citrus peel by gas chromatography Shao Jianqun, Li Qingyuan, Li Fenghua, Shi Chen, Wang Yuji, Zhang Feng Journal of Capital Medical University    2021, 42 (3): 443-446.   DOI: 10.3969/j.issn.1006-7795.2021.03.017 Abstract （535）      PDF（pc） （1264KB）（154）       Knowledge map    Save Objective To establish a method for the content determination of limonene in volatile oil from citrus peels. Methods The volatile oil was extracted by steam distillation and the content of limonene was determined by gas chromatography. Gas chromatography conditions were as follows: the capillary column was HP-5(30 m×0.32 mm×0.25 μm)with hydrogen flame ionization detector (FID), and the temperature of inlet and detector were 250 ℃. The temperature program of colum oven started at 70 ℃, holding for 16 minutes, then increased to 250 ℃ at a rate of 30 ℃·min-1, kept for 1 min. The carrier gas was nitrogen with flow rate of 1 mL·min-1. Split ration was 100∶1, and injection volume was 1 μL. Results Limonene was linear in the range of 0-17.6 mg·mL-1(r2=0.999 0). The average recovery was 103.4%(n=9), and relative standard deviation (RSD) was 2.10%(n=9). Conclusion The experiment method has good repeatability, high sensitivity and accuracy, which can be used to determine the content of limonene and control quality in volatile oil from citrus peel. Reference | Related Articles | Metrics

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Clinical Observation on Improving the Memory Impairment of Patients with Schizophrenia by Si Junzi Tang Zhou Fang;Jia Hongxiao;Tang Yunyi;Zhang Jizhi;Jiang Zhenkang Journal of Capital Medical University    2008, 29 (4): 428-430.   Abstract （812）      PDF（pc） （431KB）（430）       Knowledge map    Save Objective To investigate the improving effects on memory impairment of patients with schizophrenia by Si Junzi Tang.Methods 60 patients with schizophrenia treated by chlorpromazine were divided into two groups,one was treated with herb mixture named Si Junzi Tang,and the other with placebo.WAIS memory scales and PANNS were examined before and at the end of treatment.Another 30 healthy persons as control were also examined with above memory test.Results Before treatment,the score of memory item in treatment group and placebo group was obvious lower than that of normal control group(P<0.01).For score of digits forward,digits backward,number memory,figural memory,recognition,reproduction,association,comprehension,and MQ,except accumulation,obvious improvement was demonstrated in treatment group comparing with before treatment of itself and with placebo group(P<0.05).While there was no difference of each memory item score before and after treatment in placebo group(P>0.05).Conclusion Si Junzi Tang has some improving effects on memory impairment of schizophrenic patients. Related Articles | Metrics Cited: Baidu(2)