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Correlation between neurological deficits scores and infarct volume in focal cerebral ischemia in rats WANG Rongliang, LIU Xiaomeng, ZHANG Ying, JI Xunming, LUO Yumin Journal of Capital Medical University    2013, 34 (1): 69-74.   DOI: 10.3969/j.issn.1006-7795.2013.01.013 Abstract （1284）      PDF（pc） （3702KB）（3513）       Knowledge map    Save Objective To investigate the correlation between three scores of neurological deficits and infarct volume of middle cerebral artery occlusion (MCAO) model in rats. Methods A total of 20 Sprague-Dawley (SD) rats were randomly divided into five groups. MCAO models were induced. At five different time points (24 h, 3 d, 7 d, 14 d and 30 d after reperfusion), three grading methods (Longa test, Forelimb Placing test and Ludmila Belayev test) were used to evaluate neurological functions of rats. Then, the volume of infarction was calculated after taking the brain for HE staining. The correlations between neurological function scores and brain infarction volumes were analyzed by ANOVA and correlation.Results From 24 hours to 30 days after reperfusion, the scores of neurological deficits and the volume of infarction were decreased. There were significant differences in the scores of forelimb placing test and Ludmila Belayev test between 7 and 30 days after reperfusing (P<0.05). But the differences of infarction volume at different time points were insignificant (P>0.05). In terms of the correlation between the Ludmila Belayev score and infarction volume, there exists the obvious statistical significance at 3 (P<0.01) and 30 days (P<0.05). Conclusion For the MCAO model of rats, the Ludmila Belayev test can be used to evaluate the extent of injury after cerebral infarction at 3 and 30 days after reperfusion. Reference | Related Articles | Metrics Cited: Baidu(14)

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Research progresses in neuroprotective effects of ischemic/hypoxia preconditioning Wu Jian, Gu Yakun, Liu Jia Journal of Capital Medical University    2020, 41 (4): 664-670.   DOI: 10.3969/j.issn.1006-7795.2020.04.029 Abstract （524）      PDF（pc） （1128KB）（2043）       Knowledge map    Save The brain has poor tolerance to ischemia and hypoxia, which could result in dysfunction and pathological changes of central nervous system. Both endogenous factors such as ischemic stroke and cancer and exogenous factors such as plateau exposure, aviation, and diving can lead to ischemia and hypoxia of the body or organs. Therefore, it is of great significance to develop strategies to improve cerebral hypoxic tolerance to prevent from ischemic and hypoxic diseases. Many studies have shown that exposure to moderate ischemia and hypoxia in a short period of time can significantly strengthen the body's tolerance to subsequent more severe hypoxia. This phenomenon is known as ischemia/hypoxia preconditioning. As a neuroprotective strategy, ischemia/hypoxia preconditioning has become one of the hotspots in biomedical research, and it has been applied in a variety of preclinical models such as ischemic stroke and neurodegenerative diseases. The protective mechanism of ischemia/hypoxia preconditioning is complex, which involves hypoxia signaling pathway activation, antioxidant stress, anti-inflammatory, anti-apoptosis, and so on. In this work, we reviewed the protective mechanisms and the research progresses of ischemia/hypoxia preconditioning to highlight its application potential in the treatment of neurological diseases. Reference | Related Articles | Metrics

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Journal of Capital Medical University    2021, 42 (1): 164-166.   DOI: 10.3969/j.issn.1006-7795.2021.01.028 Abstract （181）      PDF（pc） （5479KB）（1394）       Knowledge map    Save Reference | Related Articles | Metrics

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Inqiure into the Relationship Between Caesarean Section and Severe Pregnancy-induced Hypertension Tian Shuqin Journal of Capital Medical University    1994, 15 (3): 220-223.   Abstract （549）      PDF（pc） （2305KB）（1666）       Knowledge map    Save One hundred and sixteen pregnant women complicated severe pregnancy induced hypertension(PIH)were admitted in our hospital through Jan,1991 to Aug,1993.88 of patients had caesarean section,the rate was 76.52%(88/116).The first four indications were severe pregnancy induced hypertension, CDP,intrauterine fetal distress and prolonged labour in succession.The purperal morbidity was 15.9%(14/88).The incidence of postpartum hemorrhage was 8%(7/88)and two patients developed HELLP syndrom resulting in one maternal death.There were two cases of perinatal mortality associating with non-operation causes.In this paper, the causes,increasing tendency of caesarean section rate,also the indications of caesarean section in severe PIH were discussed.The conclusion is:appropriately choicing caesarean section indications may have some advantages in decrease maternal and perinatal mortality. Related Articles | Metrics

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Conservative Operation with Laparoscopy for 60 Tube Pregnancy Cases Wang Jianjun;Li Bin;Liu Tao Journal of Capital Medical University    2005, 26 (2): 226-228.   Abstract （668）      PDF（pc） （150KB）（1807）       Knowledge map    Save Objective To investigate laparoscopic surgery effects for tube pregnancy. Methods The conservative operation was performed on 60 patients with tube pregnancy, fenestration on the position of tube pregnancy or taking out embryos from the tube crevice by laparoscopic surgery. Results The fallopian tubes of 60 patients were successfully retained with no complication occurred. β-HCG in blood recovered to normal level two weeks after operation, and the tube patency tests were carried out for 28 patients in one to six months after operation. The rate of oviduct opening was 64.29%. Conclusion Conservative operation of oviduct pregnancy by laparoscopy is safe and effective which is minimal invasion, less complication and quickly recovery. This method is especially suitable for the patients who want remaining bearing ability. Related Articles | Metrics

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Hepatotoxicity Caused by Commonly-used Chinese Medicinal Herbs and Compound Preparation Wang Xiujuan;Xu Liping;Wang Min Journal of Capital Medical University    2007, 28 (2): 220-224.   Abstract （1150）      PDF（pc） （466KB）（5479）       Knowledge map    Save The manifestations of hepatotoxicity caused by Chinese medicinal herbs are similar with ordinary liver disease. Many pathological alterations of hepatotoxicity can be seen, such as hepatocellular damage, liver disfunction, increased serum transaminase, hepatomegalia, jaundice, cholestasis, chronic hepatitis complicated with fibrosis, hepatic cirrhosis、fulminating hepatic failure, liver tumor, and etc. In most cases, the liver damage is reversible after discontinuation. The commonly-seen herbs which may cause hepatotoxicity are Huang Yao Zi(Tuber Dioscoreae Bulbiferae)、Cang Er Zi(Fructus Xanthii Sibirici)、Lei Gong Teng(Radix Tripterygum)、Ku Lian Zi(Fructus Meliae Azedarach), etc., and the compound preparations are Zhuang Gu Guan JIe Wan(The Pill for Asthritis), Ke Yin Wan(The Pill for Psoriasis), Xiao Chai Hu Tang (Xiao Bupleuri Decoction), and so on. In addition, the improper combination of Western medication and Chinese medicinal herbs may also bring about hepatotoxicity. Except the toxicity of herbs themselves, the other factors include the dosage, time, the body constitution of patients, sensitivity, seasons, and geographic regions, etc. Therefore, the medicinal herbs and their preparations should be used rationally under the guidance of the theory of traditional Chinese medicine and differentiation of symptoms, and the medical skill should be improved, which are the effective measures for avoiding hepatotoxicity. Related Articles | Metrics

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Analysis of related risk factors of colorectal adenomatous polyps Xing Jie, Ren Junyao, Zhang Qian, Sun Xiujing, Yue Bing, Zhang Yijun, Li Rongxue, Zhu Shengtao, Li Peng, Zhang Shutian Journal of Capital Medical University    2021, 42 (4): 601-608.   DOI: 10.3969/j.issn.1006-7795.2021.04.015 Abstract （318）      PDF（pc） （6328KB）（1956）       Knowledge map    Save Objective To investigate the risk factors of colorectal adenoma incidence. Methods Data of 662 patients with polypoid lesions admitted at Beijing Friendship Hospital from March 2013 to November 2014 were retrospectively collected, including the basic information such as age, gender, body mass index(BMI), family history, past medical history etc. Totally 140 cases of the patients were pathologically diagnosed as colorectal adenoma and 522 subjects of the patients were enrolled as control group. Combined with the collected data, the risk factors had been analyzed. Results The student t test showed that the age was the risk factor of colorectal adenoma (P<0.05). The chi-square test or Fisher exact test showed that the gender, smoking, drinking and polyp-growing history were correlative factors of colorectal adenoma(P<0.05). The multivariate analysis suggested the age (P<0.001), smoking (P=0.021) and drinking (P=0.022) were independent risk factors of colorectal adenoma. Conclusion The age, cigarette smoking, alcohol intake are independent risk factors of colorectal adenoma. Therefore, we should consider the relevant risk factors of the patients and screen high-risk groups to improve the detection rate of adenoma. Reference | Related Articles | Metrics

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ntelligent robot-assisted reduction system for closed reduction of femoral shaft fractures: a cadaveric study Xiao Honghu, Zhao Chunpeng, Bei Mingjian, Li Bo, Zhu Gang, Wang Yu, Song Yingchun, Wu Xinbao Journal of Capital Medical University    2024, 45 (5): 753-762.   DOI: 10.3969/j.issn.1006-7795.2024.05.003 Abstract （1141）      PDF（pc） （6211KB）（1924）       Knowledge map    Save Objective  To explore the efficacy of a self-designed intelligent robot-assisted reduction system in the closed reduction of femoral shaft fracture by a cadaveric study. Methods  Four fresh frozen cadavers (2 male and 2 female ones) were used in this study, and 8 femoral shaft fractures were created in accordance with clinical cases (AO classification, 1 case of type A1, 3 cases of type A2, 2 cases of type A3 and 2 cases of type B2). A self-designed intelligent robot-assisted reduction system was used to assist the closed reduction in the cadaveric models. Intraoperative registration time, autonomous reduction time and total operation time were recorded. The length and femoral neck anteversion before osteotomy and after reduction were measured, and the three-dimensional model of the femur before operation and after reduction was matched using Geomagic Qualify 2013 software, and the reduction error was measured to evaluate the fracture reduction accuracy and quality. Results  Effective reduction was accomplished in 8 bone models with assistance of the self-designed intelligent robot-assisted reduction system. The average intraoperative registration time was （33.3±3.7）min, the autonomous reduction time was (34.8±3.3) min, and the average total operative time was (68.0±4.1) min. The difference in length before osteotomy and after reduction was (1.6±1.6) mm, and the difference in femoral neck anteversion was (4.1±3.5)°. The mean reduction error was (4.3±2.2) mm. Conclusions  Our self-designed intelligent robot-assisted reduction system can assist in completing the closed reduction of femoral shaft fracture, with high reduction accuracy and operational feasibility, reducing the reduction time, avoiding the damage of blood supply around the fracture site, and reducing the exposure to radiation during the operation, it provides a better method for the closed reduction of femoral shaft fracture. Reference | Related Articles | Metrics

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Analysis of LI Ping;WANG Ju-sheng;ZHAO Jing-xia;WANG Ping;LIU Xin;ZHANG Guang-zhong;ZHOU Dong-mei Journal of Capital Medical University    2009, 30 (4): 413-417.   DOI: 10.3785/j.issn.1006-7795.2009.04.002 Abstract （1441）      PDF（pc） （1160KB）（3779）       Knowledge map    Save Psoriasis is one of the most common and gene-related human skin diseases. Traditional Chinese medical therapy has curative effect with fewer side effects, so the investigation of the rules of TCM differentiation and pharmacological treatment in psoriasis would provide us a new approach to improve its clinical practice. By document analysis, we proposed a hypothesis that the pathogenesis of psoriasis-'toxin accumulation in blood' means the disease happened in blood and its characteristic was 'toxin coming from excessive heat’. In addition, we elucidated the meaning of 'toxin accumulation in blood’ in the view of modern medicine, which might develop the TCM theory of 'treating psoriasis by modulating blood’. Related Articles | Metrics

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Efficacy Analysis in 13 Cases of Postpartum Hemorrhage Treated with Uterus Suture Ligation Wu Qingqing;Jiang Guiying;Chen Fei Journal of Capital Medical University    2007, 28 (1): 131-132.   Abstract （755）      PDF（pc） （126KB）（1400）       Knowledge map    Save Objective To investigate the efficacy of uterus suture ligation in 13 cases of postpartum hemorrhage. Methods Clinical data of 13 cases of postpartum hemorrhage from January, 2003 to April, 2005. Results 13 patients were stanched effectively by means of the operation of uterus suture ligation with saved without childbed infection and late postpartum hemorrhage. Conclusion Suture ligation procedure of post partum uterus is effective for hemostasia, simple and convenient. Also it is secure without any impact upon catamenia and pregnancy. Preservation of uterus will ensure the long-term quality of life of lying-in woman. Related Articles | Metrics

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Journal of Capital Medical University    2024, 45 (3): 537-542.   DOI: 10.3969/j.issn.1006-7795.2024.03.024 Abstract （125）      PDF（pc） （13875KB）（1461）       Knowledge map    Save Reference | Related Articles | Metrics

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Primary cardiac tumors:a clinicopathological analysis of 34 cases Yang Yi, Weng Yan, Li Xiangli, Li Chunfeng, Ma Ping, Xue Fang, Ruan Yingmao Journal of Capital Medical University    2016, 37 (5): 651-656.   DOI: 10.3969/j.issn.1006-7795.2016.05.019 Abstract （291）      PDF（pc） （5331KB）（1858）       Knowledge map    Save Objective To summarize histopathological features and outcome of surgical treatment of primary cardiac tumors. Methods We analyzed retrospectively clinical records and tissue sections in 34 cases of primary cardiac tumors, who were treated with surgical resection in the First Hospital of Tsinghua University from 2003 to 2015. Results Thirty-four cases were found to have primary cardiac tumors, of whom 29 had benign tumor, the most common one was myxoma (in 20 cases) and 5 cases had malignant tumors. Their age ranged from 4 months to eighty-three years (mean age=37 years) and 17 of them were male, the other 17 were female. Conclusion Primary cardiac tumor is rare. Most patients were in adolescents. There are many types in primary cardiac tumors, and their morphologic structures are complex. Most of the tumors are myxoma. Effective treatment is a surgical resection of the tumors. The prognosis is mainly dependent on pathological type, growth characteristics and location. Reference | Related Articles | Metrics

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Clinical evaluation of the factors related to the properties of the upper lobe of the lung Pan Shouqiang, Zhang Yi Journal of Capital Medical University    2016, 37 (6): 767-772.   DOI: 10.3969/j.issn.1006-7795.2016.06.010 Abstract （269）      PDF（pc） （1090KB）（1356）       Knowledge map    Save Objective To investigate the factors influencing the diagnosis of diseases of the lung' upper lobe. Methods Retrospective analysis was conducted on data of the department of thoracic surgery in Xuanwu Hospital of Capital Medical University from January 1, 2013 to January 31, 2015 according to the inclusion and exclusion criteria of the 38 patients with the upper lobe of the lung data, using SPSS 19.0 statistical software. Results In the single factor analysis in patients with anterior section space-occupation, in all the cases with CT image edge of leaf cases, the age, smoking history, carcino-embryonic antigen(CEA) and single-photon emission computed tomography(SPECT) have no radioactivity condensed had statistical significance; in all the cases with upper lobe of the left lung space-occupying, CEA and CT images of the patients with leaves had statistical significance, all in the right upper lobe anterior space-occupying cases, age, smoking history, CEA, burr of the patients, the edge of leaf were statistically significantly different. In the multifactorial analyses of cases with upper lobe of lung segment space-occupation, in all cases with the CT image edge of leaf, CEA, SPECT has no radioactive condensation had statistical significance, in all the cases with the right upper lobe anterior space-occupying cases, CEA and the edge of leaf was statistically significant. Conclusion The main factors influencing diagnosis of space-occupation in anterior segment of upper lobe of the lungs were age, smoking history, CEA and SPECT have no radioactive condensation, comprehensive analysis and evaluation, early diagnosis and early treatment are needed. Reference | Related Articles | Metrics

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Clinical features and prognostic analysis of adenoid cystic carcinoma of the external auditory canal Wu Jun, Zhao Xi, Ma Tingyao, Yang Guoliang, Zhang Shujing, Zhao Yue, Liu Yixuan, Chen Xiaohong Journal of Capital Medical University    2025, 46 (3): 559-566.   DOI: 10.3969/j.issn.1006-7795.2025.03.022 Abstract （253）      PDF（pc） （963KB）（1958）       Knowledge map    Save Objective  To investigate the clinical characteristics, treatment strategies, and prognostic factors of adenoid cystic carcinoma (ACC) of the external auditory canal (EAC), and to provide evidence for optimizing surgical extent and adjuvant therapy. Methods  A retrospective cohort study was conducted on 58 patients with pathologically confirmed ACC of the EAC treated in Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, between January 2001 and December 2021. All patients underwent surgical treatment, with some receiving adjuvant radiotherapy. The primary outcome was local recurrence, while secondary outcomes included overall survival (OS) and local recurrence-free survival (LRFS). Survival analysis was performed by the Kaplan-Meier method, and Cox regression models were used to identify risk factors for recurrence. Results  The median follow-up time for the entire cohort was 6.27（3.25, 11.30）years. The 1-year, 3-year, and 5-year OS rates were 96.55%, 91.37%, and 89.66%. 43.10% of cases were classified as T4 stage at diagnosis, indicating advanced local progression. Local recurrence occurred in 23 patients (39.66%), and distant metastasis was observed in 28 patients (48.28%), with pulmonary metastasis accounting for 92.86% of cases. Multivariate analysis revealed that the solid histological pattern (HR=2.729, 95% CI: 1.025－7.226, P=0.044) and perineural invasion (PNI) (HR=9.891, 95% CI: 3.525－27.752, P<0.01) were independent risk factors for local recurrence. Conclusion  ACC of the EAC is characterized by a high propensity for local recurrence and distant metastasis. The solid histological pattern and perineural invasion are critical prognostic determinants. Multimodal therapy (surgery combined with adjuvant radiotherapy) may improve clinical outcomes, and early diagnosis and intervention are pivotal for enhancing survival rates. Reference | Related Articles | Metrics

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Analysis of risk factors and identification of high-risk patients for recurrent stroke in symptomatic intracranial and extracranial atherosclerotic stenosis Tian Xue, Xia Xue, Zhou Quan, Yang Weizi, Hao Yunyi, Sun Yue, Wang Anxin, Zhang Tong Journal of Capital Medical University    2026, 47 (1): 43-53.   DOI: 10.3969/j.issn.1006-7795.2026.01.006 Abstract （790）      PDF（pc） （562KB）（1331）       Knowledge map    Save Objective  To screen and validate risk factors associated with stroke recurrence in Chinese patients with symptomatic intracranial and extracranial atherosclerotic stenosis and to identity patients at high-risk of stroke recurrence. Methods  This study utilized data from the Third China National Stroke Registry. Patients with stroke and ≥50% intracranial or extracranial arterial stenosis were included. The data collected included demographic characteristics, medical history, prehospital care, physical examination findings on admission, admission scores, imaging information, discharge diagnoses, and laboratory parameters. The primary outcome was ascertained as stroke recurrence within 3 months. Cox proportional hazards regression was used to identify independent risk factors for stroke recurrence in symptomatic intracranial and extracranial atherosclerotic stenosis patients. A prediction model for 3-month stroke recurrence was developed based on the identified factors and its predictive performance was compared with the traditional ESSEN score. Results  Among 3 944 enrolled patients (median age 64 years,  67.8% male), 324 (8.7%) patients experienced stroke recurrence within 3 months. Multivariable Cox regression analysis identified the following independent risk factors for recurrence: age≥75 years (HR=1.36, 95% CI: 1.06-1.76, P=0.016), time from onset to admission <72 h (HR=1.64, 95% CI: 1.14-2.35, P=0.007), admission National Institutes of Health Stroke Scale (NIHSS) >5 (HR=3.38, 95% CI: 1.13-10.14, P=0.029), non-lacunar infarction (HR=1.71, 95% CI: 1.13-2.57, P=0.011), and elevated plasma interleukin-6 level (HR=1.02, 95% CI: 1.00-1.05, P=0.040). The novel prediction model demonstrated superior discriminative ability compared to the ESSEN score, with the C-statistic increasing from 0.557 to 0.616 (P=0.003). Significant improvements were also observed in integrated discrimination improvement (IDI=0.79%, 95% CI： 0.44%-1.14%, P<0.001) and net reclassification index (NRI=21.34%, 95% CI: 10.88%-31.80%, P<0.001).Conclusion  In Chinese patients with symptomatic intracranial and extracranial atherosclerotic stenosis, age≥75 years, onset-to-admission time <72 h, admission NIHSS >5, non-lacunar infarction, and elevated plasma interleukin-6 levels are independent risk factors for 3-month stroke recurrence. The prediction model incorporating these factors outperforms the conventional ESSEN score in identifying patients at high-risk of stroke recurrence. Reference | Related Articles | Metrics

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Clinical Observation of Peptic Ulcer in the Aged Zhao Jun;Zhang Taichang Journal of Capital Medical University    2004, 25 (2): 230-232.   Abstract （754）      PDF（pc） （294KB）（1483）       Knowledge map    Save To identify the characteristics of peptic ulcer in the aged in relation to diagnosis and treatment. Analysis was made regarding location of ulcer and frequency of complications in 63 cases of peptic ulcer in the aged hospitalized between 2001-2002. Results: Large area peptic ulcer in aged peptic ulcer is as high as 27.0% of total cases reported, Among the complications, bleeding was the initial symptom, there are 17.5% syncope cases and 17.5% peptic perforation, regular upper abdominal pain is rare. In peptic ulcer among aged persons, the symptom is atypical, so diagnosis is easy to be delayed with many other illness as complications, which increases mortality. Gastroendoscopic diagnosis in time and treatment for bleeding are crucial. Operation in appropriate time also affects the prognosis. Anti-HP treatment prominently decreases recurrence of peptic ulcer. Related Articles | Metrics

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Inflammatory Pseudotumors of the Lung:Clinical Analysis of 32 Cases Ye Dangshi;Qiu Xinsun Journal of Capital Medical University    1986, 7 (4): 279-281,335.   Abstract （533）      PDF（pc） （2964KB）（1469）       Knowledge map    Save In this paper 32 cases of inflammatory pseudotumors of the Lungare reported.They were sclerosing hemagioma in 17 cases,histiocytomain 14 cases and plasma cell granuloma in one.Before and duringoperation,the misdiagnosis rates were 93.8% and 87.5% respectively.The definite diagnosis rates in frozen section was 23.1%(3/13).25cases(78%)were misdiagnosed for more than 3 months,with the longestbeing 12 years.The causes of misdiagnosis,the diagnosis ofinflammatory pseudotumors of the lung,and the main points of thedifferential diagnosis to pulmonary tuberculoma,peripkeral type of lungcarcinoma,pulmonary hamartoma,adenoma and localized,mesotheliomaof pleura were disscused. Related Articles | Metrics

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Model of Middle Cerebral Artery Occlusion in New Zealand Rabbits YAN Feng, JI Xun-ming, XUAN Yun, TIAN Xin, ZHANG Chen-cheng, LUO Yu-min, Journal of Capital Medical University    2010, 31 (1): 79-83.   DOI: 10.3969/j.issn.1006-7795.2010.01.018 Abstract （1543）      PDF（pc） （722KB）（1304）       Knowledge map    Save Objective To establish a modified middle cerebral artery occlusion(MCAO) model in the rabbit through a novel hollow filament based on the intraluminal suture method, to provide a new modal for studying the cerebrovascular disease. Methods The rabbit was anesthetized and fixed and the distal common carotid artery(CCA), internal carotid artery(ICA), and external carotid artery(ECA) of the rabbit were exposed. A modified PE-50 catheter(a novel hollow filament) had been introduced into the ICA through the incision of ECA and the filament was lodged in the narrow proximal anterior cerebral artery(ACA) and blocked the MCA at its origin. The neurological functional scores were evaluated at 24 h after the operation. Then the rabbits were sacrificed and 2, 3, 5-triphenyltetrazolium chloride(TTC) staining was used to determine the infarct volume. Results The pH values, PO2, PCO2, mean arterial blood pressure(MABP), and glucose were not affected by the operation. The cerebral blood flow(CBF) decreased by 45.8%±16.2 after ischemia. The neurological functional scores varied in each rabbit. The percentage of the infarct volume was 9.43%±5.37%. The rate of success was 54.3% for the model. Most rabbits died of the subarachnoid hemorrhage. Conclusion The model can be used for the study of cerebral ischemia by monitoring the cerebral blood flow and careful operation although the ratio of success was not very high. Related Articles | Metrics Cited: Baidu(1)

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Surgical technique of cochlear implantation in patients with facial nerve developmental abnormalities obstructing round window Cui Danmo, Xue Shujin, Wei Xingmei, Chen Biao, Zou Xinyue, Li Yongxin Journal of Capital Medical University    2024, 45 (6): 989-994.   DOI: 10.3969/j.issn.1006-7795.2024.06.007 Abstract （874）      PDF（pc） （6764KB）（1660）       Knowledge map    Save Objective  To  explore the application of  the surgical technique of cochlear implantation (CI) in patients with facial nerve developmental abnormalities obstructing round window. Methods  A retrospective analysis  of medical history, audiological data, imaging data and surgical methods was conducted on the clinical data of 6 severely or extremely severely deaf patients with facial nerve developmental abnormalities obstructing round window from March 2009 to July 2023. Results  Among the 6 patients, 1 patient underwent oval window implantation, 2 patients underwent retro-facial approach implantation, and 3 patients underwent ear canal or ear canal/posterior combined approach implantation. Six patients were successfully implanted with electrodes. One patient showed no significant change in facial paralysis after surgery compared to before, and the others did not experience facial nerve damage after surgery. all 6 patients experienced complications such as collapse of the posterior wall of the external auditory canal and cerebrospinal fluid ear fistula. Conclusions  When abnormal facial nerve development is found during CI surgery in patients with severe or extremely severe hearing loss, various pathways can be selected based on the shape of the facial nerve to complete cochlear electrode implantation. Reference | Related Articles | Metrics

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Clinical Characteristics of the Elderly with Metabolic Syndrome HONG Xu;MA Qing;CHEN Hai-ping;YU Heng-chi;YIN Jie;HAO Ya-bin Journal of Capital Medical University    2009, 30 (5): 691-695.   DOI: 10.3969/j.issn.1006-7795.2009.05.025 Abstract （1298）      PDF（pc） （1024KB）（1904）       Knowledge map    Save Objective To investigate clinical characteristics of the elderly with metabolic syndrome and type 2 diabetes and the influence of metabolic syndrome on coronary heart disease and chronic renal disease. Methods The study was conducted in 257 patients(age range 60-85 years) with type 2 diabetes mellitus. The patients were divided into two groups which were with or without MS according to the Adult Treatment Panel Ⅲ criteria:120 patients with MS and 137 patients without MS.The clinical features and morbidity of coronary heart disease, arteriosclerosis of the lower extremity, and cerebral infarction. Results Compared with patients without MS, BMI, HOMA-β, total cholesterol, triglyceride, uric acid and microalbuminuria of patients with MS were significantly higher(all P<0.01). Compared with patients without MS, more patients with MS suffered from CHD(P<0.01). Conclusion Obesity,dyslipidemia, insulin resistance, hyperuricacidemia, microalbuminuria and CHD were more common in the elderly with MS and type 2 diabetes. Related Articles | Metrics Cited: Baidu(4)