关键词: 尿毒症, 血液透析, 肺功能

Abstract: Objective To analyse the pulmonary function and related factors in uremic patients on hemodialysis.Methods To determine the pulmonary function of forty-nine patients with uremia(19 patients who were not on hemodialysis,30 patients who were on hemodialysis） and 30 healthy persons.Correlative analysis was performed between parameter such as pulmonary function index and hemoglobin,plasma total albumin,albumin,Bun,Cr in hemodialysis patients;Analyze the relation between pulmonary function and chest X-ray.Results There was significant difference existed between uremic,hemodialysis patients and healthy person(P<0.01,respectively）.The index of forced vital capacity expressed as percentages of predicted normal values(FVC%）,forced expiratory volume in one second expressed as percentages of predicted normal values(FEV₁%),forced expiratory flow rate in one second(FEV₁/ FVC%),forced expiratory flow between 25% and 75% of vital capacity expressed(FEF25%～75%）,pulmonary diffusion capacity for carbon monoxide expressed as percentages of predicted normal values(DLCO%） were much lower in uremia,hemodialysis patients.There were obvious increase of ventilation and dispersion function after uremic patients on hemodialysis(P<0.05）.There was a strong correlation between pulmonary dispersion function and hemoglobin(P<0.05）.Conclusion There was obvious lowering of pulmonary function in uremia,anemia was one of the causes to influence the dispersion function.It is necessary to make hemodialysis and cure anemia in order to improve pulmonary function of uremic patients.

Key words: uremia, hemodialysis, pulmonary function