首都医科大学学报 ›› 1985, Vol. 6 ›› Issue (4): 257-258,290.

• 论著 • 上一篇    下一篇

去甲斑蝥素对实验性肝炎的药理研究Ⅰ对四氯化碳中毒性肝脏损伤的保护作用

孙骏奇1, 甘哲1, 王丽娟1, 温祥云2   

  1. 1. 北京第二医学院药理学教研室;2. 北京第二医学院病理解剖学教研室
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:1985-10-15 发布日期:1985-10-15

Pharmacological Effect of Cantharidin on Experimental Hepatitis Ⅰ. Preventive Effect of Cantharidin on Toxic Hepatic Damages Induced by Carbon Tetrachloride

Sun Zunqi1   

  • Received:1900-01-01 Revised:1900-01-01 Online:1985-10-15 Published:1985-10-15

PDF

189

被引次数

19

摘要：

本文初步探讨了不同剂量的去甲斑蝥素对急性实验性肝炎的保护作用。以四氯化碳造成的急性实验性肝炎为模型,结果表明小剂量和中等剂量的去甲斑蝥素能有效地对抗四氯化碳所致的肝脏损害和血清酶GPT的升高,而特大剂量的去甲斑蝥素本身可产生肝脏损害和GPT的升高。

Abstract:

Acute experimental hepatitis induced by carbon. tetrachloride (CCl4) is one of the classical animal models used in laboratory. The present paper showed that low and moderate doses of cantharidin prevented effectively the hepatic damage and increased in serum level of GPT in these models. Whereas extra-high doses of cantharidin might also lead to hepatic damage and increase in GPT level, but such changes were much less milder than that induced by CCl4.

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