抗HCG抗体IgG-F(ab')2对HCG所致小鼠子宫效应的中和作用

首都医科大学学报 ›› 1985, Vol. 6 ›› Issue (2): 131-133.

抗HCG抗体IgG-F(ab')₂对HCG所致小鼠子宫效应的中和作用

吉重华¹, 王育英²

1. 北京第二医学院微生物学教研室;2. 北京市妇产医院计划生育研究室

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:1985-04-15 发布日期:1985-04-15

Investigation on the ability of F (ab')₂ Fragment of Anti--HCG--IgG to Neutralize the Uterine Effect of HCG in Mice

Ji Zhonghua¹

Received:1900-01-01 Revised:1900-01-01 Online:1985-04-15 Published:1985-04-15

摘要/Abstract

摘要： 以小鼠子宫增重法及子宫的组织学检查对抗HCG抗体IgG—F(ab')₂对HCG的中和作用进行了研究。当用低稀释度F(ab')₂片段进行中和时,子宫未出现有意义的子宫增重及内膜增生,当用较高稀释度F(ab')₂片段进行中和时,子宫内膜呈高度水肿、充血及炎细胞浸润,腺体也未见明显增生。本文结果指出,抗HCG抗体与HCG发生中和作用时,抗体的Fc段是不需要的。

Abstract: The neutralization of F (ab')₂ fragment of anti-HCG-IgG with HCG was investigated using mouse uterine weight assay and uterine histological examination. No significant increase in uterine weight and endometrial hyperplasia were observed in low dilution of F (ab')₂ fragment of anti-HCG-IgG. The endometrial hyperplsia was not found on histological section, but in relatively high dilution, a serious uterine edema and hyperemia with infiltration of phagocytes occurred. These investigations show that the Fc portion of anti-HCG is not roquired in the neutralization with HCG.

吉重华;王育英. 抗HCG抗体IgG-F(ab')₂对HCG所致小鼠子宫效应的中和作用[J]. 首都医科大学学报, 1985, 6(2): 131-133.

Ji Zhonghua. Investigation on the ability of F (ab')₂ Fragment of Anti--HCG--IgG to Neutralize the Uterine Effect of HCG in Mice[J]. Journal of Capital Medical University, 1985, 6(2): 131-133.

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抗HCG抗体IgG-F(ab')₂对HCG所致小鼠子宫效应的中和作用

Investigation on the ability of F (ab')₂ Fragment of Anti--HCG--IgG to Neutralize the Uterine Effect of HCG in Mice

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