首都医科大学学报 ›› 1988, Vol. 9 ›› Issue (1): 1-6.
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杨兵, 吕国蔚
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Yang Bing, Lu Guowei
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摘要： 用银球电极在麻醉、麻痹大鼠腰膨大处记录刺激腓神经引起的脊髓场电位(SFP),观察其在5-HT作用下的变化状况。结果表明,在本实验剂量下,腹腔注射左旋-5羟色胺酸(L-5HTP)后SFP未见显著改变;静脉注射L-5HTP后SFP的N、P波出现显苫升高或显著降低两种变化;局部施加5-HT后,N、P波只出现显著降低;A波在任何处理中均未见到显著改变。结果提示,5-HT可能主要通过抑制中间神经元的活动和以突触前及(或)突触后抑制作用影响N、P波的形成。
关键词: 5-羟色胺, 脊髓场电位, 脊髓中间神经元, 突触前和(或)突触后抑制
Abstract: The experiments were carried on anesthetized and immobilized rats, and the change of spinal field potentials (SFP) was observed when L-5HTP or 5-HT was given. No change was seen in SFP during intraperi-tonial injection of L-5HTP solution. The amplitudes of waves N and P reduced or increased in equal number following intravenous injection of L-5HTP.Only decrease in magnitude of waves N and P was shown when 5-HT was locally applied. No change in wave A's amplitude could be observed in all experimental groups. The results indicate that 5-HT may influence formation of waves N and P mainly via suppression of the activity of interneurons as well as pre-and/or postsynaptic inhibition.
Key words: 5-hydroxytryptamine, spinal field potential, spinal interneurons, pre-and/or postsynaptic inhibition
杨兵;吕国蔚. 5-羟色胺对大鼠脊髓场电位的影响[J]. 首都医科大学学报, 1988, 9(1): 1-6.
Yang Bing;Lu Guowei. Effect of 5-hydroxytryptamine on Spinal Field Potential in the Rat[J]. Journal of Capital Medical University, 1988, 9(1): 1-6.
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链接本文: https://journal03.magtech.org.cn/Jweb_sdykdxxb/CN/
https://journal03.magtech.org.cn/Jweb_sdykdxxb/CN/Y1988/V9/I1/1
