MP0090对约氏鼠疟原虫孢子增殖期作用的透射电镜初步观察

首都医科大学学报 ›› 1988, Vol. 9 ›› Issue (3): 174-178.

MP0090对约氏鼠疟原虫孢子增殖期作用的透射电镜初步观察

邵平, 孔德芳, 王瑞芳

首都医学院寄生虫学教研室

收稿日期:1987-10-01 修回日期:1900-01-01 出版日期:1988-07-15 发布日期:1988-07-15

TME Observation on the Effects of MP0090 on the Sporogony of Plasmodium yoelii yoelii

Shao Ping

Department of Parasitology, Capital Institute of Medicine

Received:1987-10-01 Revised:1900-01-01 Online:1988-07-15 Published:1988-07-15

摘要/Abstract

摘要： 对感染约氏鼠疟原虫配子体的小鼠分别一次灌服MP0090 5mg/kg和10mg/kg,2小时后供斯氏按蚊血餐。于第7、9、11天分别解剖蚊胃;透射电镜观察。可见经两组药物作用的卵囊发育受抑制,其内胞质粗糙并出现许多空泡,正常结构几乎消失。在某些卵囊内,即使成孢子细胞已形成,但子孢子也呈现明显的空泡状。结果表明:MP0090具有间接阻断孢子增殖的作用,且浓度不同作用效果亦不同。

关键词: MP0090, 约氏鼠疟原虫-斯氏按蚊系统, 配子体, 孢子增殖, 间接阻断

Abstract: It is reported in this paper that the mice infected with P.y.y. game-tocytes were administe red for a dose of MP0090 5mg and 10mg/kg respe-ctively, 2 hours later, they were blood-mealed by Anopheles stephensi. We dissected the mosquito’s midguts on the 7th, 9th and 11th day, and observed them under TME. It was seen that the number of oocysts affected by the two doses decreased evidently. The growth of oocysts was rest-rained. As a result, there were numerous vacuoles in the oocyst, and the normal structure almost disappeared. The sporozoites also presented vacuoles markedly. The results showed that the drug MP0090 can inhibit sporogony indirectly, and the inhibition can become stronger with the increase of the concentration of the drug.

Key words: 5-p-fluoro-phenoxyl-prima quire citrate, gametocyte, sporogony, Plasmodium yoelii yoelii-Anopheles stephensi system, indirect inhibition

邵平;孔德芳;王瑞芳. MP0090对约氏鼠疟原虫孢子增殖期作用的透射电镜初步观察[J]. 首都医科大学学报, 1988, 9(3): 174-178.

Shao Ping. TME Observation on the Effects of MP0090 on the Sporogony of Plasmodium yoelii yoelii[J]. Journal of Capital Medical University, 1988, 9(3): 174-178.