橡胶防老剂D对大鼠肝、肺药物代谢酶的影响

首都医科大学学报 ›› 1987, Vol. 8 ›› Issue (2): 105-108.

橡胶防老剂D对大鼠肝、肺药物代谢酶的影响

邢卫荣, 李永顺, 蒋致诚, 苏忆兰, 蒋建民

首都医学院卫生学教研室

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:1987-04-15 发布日期:1987-04-15

The Effects of Antioxidant D on Drug-metabolizng Enzymes of the Liver and the Lungs in Rats

Xing Weirong

Department of Public Health

Received:1900-01-01 Revised:1900-01-01 Online:1987-04-15 Published:1987-04-15

摘要/Abstract

摘要： 防老剂D是以N-苯基-β-萘胺为主要成份的通用橡胶防老剂。本文探讨了防老剂D对大鼠肝、肺药物代谢酶的影响。实验结果发现防老剂D可缩短小鼠戊巴比妥钠诱导的睡眠时间,提高肝脏器系数,细胞色素P450含量和NADPH-细胞色素C还原酶、谷胱甘肽S转移酶和肝、肺多环芳烃羟化酶、乙基吗啡脱甲基酶,对-硝基茴香醚脱甲基酶的活性。使肝、肺细胞内质网增生。

关键词: 防老剂 D, 细胞色素 P-450, 药物代谢酶, 混合功能氧化酶, 谷胱甘肽S转移酶

Abstract: The antioxidant Dmainly containing N-phenyl-2-naphthyl-amine was a pollutant of the rubber industry,In this paper the influences of antioxidant Don drug-metabolizing enzymes of the liver and the lungs of the rat were studied.The results indicated that the antioxi-dant Ddecreased the mouse sleep time induced by pentobarbital sodium and increased the organ coefficient,the content of the hepatic microso- mal cytochrome P-450,the activities of the NADPH-Cytochrome Creductase of the hepatic microsome,GSH S-transferase of the liver S₉ and benzopyrene hydroxylase,ethylmorphine demethylase,p-nitroani- sole demethylase of the liver and the lungs.The antioxidant Dcould stimulate proliferation of smooth endoplasmatic reticulum of the liver cells and the lung cells.

Key words: antioxidant D, cytochrome P-450, drug metabolizing enzymes, mixed function oxidase, GSH S-transferase

邢卫荣;李永顺;蒋致诚;苏忆兰;蒋建民. 橡胶防老剂D对大鼠肝、肺药物代谢酶的影响[J]. 首都医科大学学报, 1987, 8(2): 105-108.

Xing Weirong. The Effects of Antioxidant D on Drug-metabolizng Enzymes of the Liver and the Lungs in Rats[J]. Journal of Capital Medical University, 1987, 8(2): 105-108.

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[2]	邢卫荣;苏忆兰;蒋建民. 橡胶防老剂D致突作用研究[J]. 首都医科大学学报, 1987, 8(3): 190-192.
[3]	袁寀;吕式琪;姚娴. 氧化苦参碱对小鼠肝微粒体药物代谢酶的诱导作用[J]. 首都医科大学学报, 1987, 8(1): 23-26.