首都医科大学学报 ›› 1989, Vol. 10 ›› Issue (1): 32-36.

• 论著 • 上一篇    下一篇

人红细胞钠泵及大黄对其影响的研究

袁振铎, 狄华, 徐婉珍   

  1. 北京友谊医院北京市临床医学研究所
  • 收稿日期:1988-03-17 修回日期:1900-01-01 出版日期:1989-01-15 发布日期:1989-01-15

Studies of the Erythrocyte Sodium Pump Activity in Human and Effect of P. Palmatum on it

Yuan Zhenduo   

  1. Beijing Clinical Medicine Institute, Beijing Friendship Hospital
  • Received:1988-03-17 Revised:1900-01-01 Online:1989-01-15 Published:1989-01-15

摘要: 用(30)~Rb摄入法研究了人红细胞钠泵的阳离子转运活性。在实验的最适条件下,测定了正常人70例红细胞钠泵活性,其值为0.449±0.059mmol/(L·h)(X±SD)。在此基础上观察了大黄液在体外对人红细胞钠泵活性的抑制作用。讨论了大黄降温机理与大黄抑制钠泵的关系。研究提示了钠泵活性异常在细胞产热的病理生理学上的可能作用。

关键词: 大黄, 红细胞钠泵, 80Rb摄入法

Abstract: The cation-transport activity of the human erythrocyte sodium pump Was studied with 86rubidium uptake method. We chose the experimental optimum conditions and measured the activity of erythrocyte sodium pump in 70 normal individuals (0.449±0.059mmol/ (L·h).X±SD). The inhi- bitory activity of P. Palmatum on the human erythrocyte sodium pump in vitro was also observed, Our studies suggest that abnormal sodium pump activity may play a role in the pothophysiology of cellular thermogenesis.

Key words: P. Palmatum, erythrocyte sodium pump activity, 86Rb uptake method