实验性IgA肾病的肝脏改变

首都医科大学学报 ›› 1990, Vol. 11 ›› Issue (3): 203-205.

实验性IgA肾病的肝脏改变

董小黎, 郑国芬, 吴智敏

1. 首都医学院病理解剖学教研室

收稿日期:1990-01-10 修回日期:1900-01-01 出版日期:1990-07-15 发布日期:1990-07-15

Hepatic Lesiens in Experimental IgA Nephropathy

Dong Xiaoli, Zheng Guofen, Wu Zhimin

Department of Patho-anatomy Capital Insitiute of Medicine

Received:1990-01-10 Revised:1900-01-01 Online:1990-07-15 Published:1990-07-15

摘要/Abstract

摘要： 对实验性四氯化碳性肝硬变所致IgA肾病的大鼠肝脏进行PAP法免疫组织化学染色,以观察肝脏改变。结果表明,用药22-1061大鼠肝窦的枯否氏细胞、肝窦基底膜和汇管区的巨噬细胞以及个别肝细胞浆内均有明显的IgA沉着,IgG着色非常弱。肝脏IgA沉积出现的时间先于肾脏IgA。此外还就肝肾IgA沉积的机理及肝脏IgA沉积与肝脏硬变的关系进行了探讨。

关键词: 肝硬变, IgA沉积物, IgA肾病

Abstract: Hepatic lesions in experimental IgA nephropathy induced by CC1₄ cirrhosis of rats were demonsratted by PAP immuno-histoehemical method, IgA was found in the hepatic sinusoids, Kupffer's cells, phagocytes of portal regions and isolated hepatocytes. IgA deposits appeared earlier in the liver than in the kidney. IgG was also found in the hepatic tissues.

Key words: cirrnosis, IgA deposit, IgA nephropathy

董小黎;郑国芬;吴智敏. 实验性IgA肾病的肝脏改变[J]. 首都医科大学学报, 1990, 11(3): 203-205.

Dong Xiaoli;Zheng Guofen;Wu Zhimin. Hepatic Lesiens in Experimental IgA Nephropathy[J]. Journal of Capital Medical University, 1990, 11(3): 203-205.

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[2]	周楠;沈颖;焦莉平;王辉;孟群. IgA肾病早期肾脏局部RAS的活化与调节[J]. 首都医科大学学报, 2005, 26(5): 549-554.
[3]	郑国芬;董小黎;吴位育. 实验性IgA肾病[J]. 首都医科大学学报, 1989, 10(1): 6-8.
[4]	郑国芬;吴位育;董小黎;吉重华. 四氯化碳性肝硬变大鼠的肾脏病变[J]. 首都医科大学学报, 1988, 9(2): 79-83.