大鼠对银耳多糖铁(Ⅲ)配合物中铁吸收的初步研究

首都医科大学学报 ›› 1992, Vol. 13 ›› Issue (3): 177-180.

大鼠对银耳多糖铁(Ⅲ)配合物中铁吸收的初步研究

王桥¹, 曾昭晖²

1. 首都医学院化学教研室;2. 首都医学院仪器分析室

收稿日期:1991-05-23 修回日期:1900-01-01 出版日期:1992-07-15 发布日期:1992-07-15

A Primary Study on the Absorption of Iron from Iron (Ⅲ)—Tremella Fuciformis Polysaccharide Complex in the Rats

Wang Qiao¹, Zeng Zhaohui²

1. Department of Chemistry, Capital Institute of Medicine;2. Laboratory of Instrumental Analysis, Capital Institude of Medicine

Received:1991-05-23 Revised:1900-01-01 Online:1992-07-15 Published:1992-07-15

摘要/Abstract

摘要： 研究了银耳多糖铁(Ⅲ)配合物在pH4～12的水解情况,未观察到有沉淀生成,可望有较好的生物利用度。通过大鼠静注给药测得其在体内的消除是一级动力学,属于一室模型药物。分别给大鼠服用银耳多糖铁(Ⅲ)配合物和FeSO₄实验结果表明:大鼠对银耳多糖铁(Ⅲ)配合物的吸收率高,消除速率常数小,铁在血清中维持较高浓度的时间长,并测得其生物利用度是72%,是FeSO₄的1.5倍。

关键词: 补铁剂, 多糖铁(Ⅱ)配合物, 铁吸收, 生物利用度

Abstract: The hydrolysis of Iron (Ⅲ)-tremella fuciformis polysaccharide complex (ITC) was stu-died at pH values ranging from 4 to 12 and no precipitates were observed so that it may have better bioavailability. Intravenously injecting to the rats, its elimination kinetic was found to be the first order and one compartment model. ITC exhibtied higher absorption, smaller elimination and longer duration of high serum iron concentration than that of FeSO₄ when rats were fed with ITC and FeSO₄, respectively. The bioavailability of ITC was 72% which was 0. 5 times higher than that of FeSO₄.

Key words: iron-supplementary, iron (Ⅲ)-polysaccharide complexes, absorption of iron, bioavailability

中图分类号:

R313

王桥;曾昭晖. 大鼠对银耳多糖铁(Ⅲ)配合物中铁吸收的初步研究[J]. 首都医科大学学报, 1992, 13(3): 177-180.

Wang Qiao;Zeng Zhaohui. A Primary Study on the Absorption of Iron from Iron (Ⅲ)—Tremella Fuciformis Polysaccharide Complex in the Rats[J]. Journal of Capital Medical University, 1992, 13(3): 177-180.

[1]	王桥;曾昭晖. 银耳多糖铁(Ⅲ)配合物的合成及其理化性质的研究[J]. 首都医科大学学报, 1991, 12(4): 270-274.
[2]	曾昭晖;张玉珍;刘永利. 糊精—柠檬酸—Fe(Ⅲ)配合物的合成及其性能研究[J]. 首都医科大学学报, 1990, 11(1): 14-17.