重组人促红细胞生成素治疗慢性肾功能不全贫血25例临床观察

首都医科大学学报 ›› 1992, Vol. 13 ›› Issue (2): 124-127.

重组人促红细胞生成素治疗慢性肾功能不全贫血25例临床观察

陈秉良, 吴耀炯, 贾强, 魏世民, 高国静, 孙延兵, 姚峥

首都医学院宣武医院肾科

收稿日期:1991-12-12 修回日期:1900-01-01 出版日期:1992-04-15 发布日期:1992-04-15

Clinical Observation of Therapeutic Effect of Recombinant Human Erythropoietin in 25 Chronic Renal Insufficiency Patients

Chen Bingliang, Wu Yaojiong, Jia Qiang, Wei Shimin, Gao Guojing, Sun Yanbing, Yao Zheng

Department of Nephrdogy, Xuanmu Hospital, Capital Institute of Medicine

Received:1991-12-12 Revised:1900-01-01 Online:1992-04-15 Published:1992-04-15

摘要/Abstract

摘要： 对25例慢性肾功能不全贫血病人(IR液透析维持状态15例,非透析病人10例)用重组人促红细胞生成素(r-HuEPO)治疗6个月并进行了观察,用r-HuEPO 6～9周后有23例病人Hb达到理想水平,平均Hb 106±8 g/L,hct 0.331±0.029。透析病人和非透析病人各1例用r-HuEPO后无效。5例合并血小板减少和3例合并白细胞减少的病人用r-HuEPO 12周后各有1例恢复正常。病人一般症状明显好转。贫血改善后病人平均动脉压升高,血液透析病人用r-HuEPO前为12.5±2.39 kPa(94±18mmHg),用r-HuEPO 3个月时上升至14.36±0.74 kPa(108±5.6 mmHg,P<0.05);非透析病人用r-HuEPO前为12.77±2.26 kPa(96±17mmHg),用r-HuEPO 3个月时为14.89±0.89 kPa(112±6.7mmHg,P<0.05)。病人内生肌酐清除率、血肌酐、尿素氮、钙、磷、尿酸、24h尿蛋白定量在用r-HuEPO后3个月和6个月与用r-HuEPO前无显著改变。

关键词: 贫血, 重组人促红细胞生成素, 慢性肾功能不全

Abstract: 25 anemia patients caused by chronic renal insufficiency, 15 patients kept haemodialy-sis, the other received nondialysis treatment, were given recombinant human erythropoietin (r-HuEPO) thrice a week intravenously. Haemoglobin(Hb) rose to 106±8 g/L in 23 cases after 6～8 weeks accompanying increased life quality. 1 of 5 eases with low platelets counts and 1 of 3 cases with low leukocytes returned to normal 12 weeks after r-HuEPO adminis-tration. Mean WBC and platelets counts increased 12 weeks after r-HuEPO therapy. Mean blood pressure increased while haemoglobin rose. No significant changes were found in serum creatinine, uria, calcium, phosphorus, uric acid, cretinine clearance and 24h proteinurea amount.

Key words: anemia, r-HuEPO, chronic renal insufficiency

中图分类号:

R692.5

陈秉良;吴耀炯;贾强;魏世民;高国静;孙延兵;姚峥. 重组人促红细胞生成素治疗慢性肾功能不全贫血25例临床观察[J]. 首都医科大学学报, 1992, 13(2): 124-127.

Chen Bingliang;Wu Yaojiong;Jia Qiang;Wei Shimin;Gao Guojing;Sun Yanbing;Yao Zheng. Clinical Observation of Therapeutic Effect of Recombinant Human Erythropoietin in 25 Chronic Renal Insufficiency Patients[J]. Journal of Capital Medical University, 1992, 13(2): 124-127.

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