急性重复缺氧对BALB/C小鼠缺氧耐受性的影响

首都医科大学学报 ›› 1995, Vol. 16 ›› Issue (4): 249-252.

急性重复缺氧对BALB/C小鼠缺氧耐受性的影响

李凌, 吕国蔚, 安仰原

首都医学院神经生物学研究室

收稿日期:1995-04-10 修回日期:1900-01-01 出版日期:1995-10-15 发布日期:1995-10-15

Effects of Acute Repeated Hypoxia on Hypoxia Tolerance of BALB/C Mice

Li Ling, Lu Guowei, An Yangyuan

Department of Neurobiology, Capital Institute of Medicine

Received:1995-04-10 Revised:1900-01-01 Online:1995-10-15 Published:1995-10-15

摘要/Abstract

摘要： 观察重复缺氧对BALB/C小鼠缺氧耐受性的影响。结果在密闭缺氧的重复作用下,BALB/C小鼠第1次缺氧的耐受时间平均为17.3min,第2、3、4次缺氧的耐受时间分别为第1次的3、6、7倍。第4次重复缺氧后,小鼠在低氧分压和氰化钾作用下的存活时间分别较正常对照小鼠增加26倍与2.6倍。结果提示,急性重复缺氧显着增加BALB/C小鼠对缺氧的耐受性。

关键词: 重复缺氧, 低压舱, 氰化钾中毒, BALB/C小鼠

Abstract: With repeated exposure of BALB/C mice to hypobaric hypoxia,the tolerance time of the mince in the first run of exposure was 17.3 min in average and those of the subsequent 2nd,3rd and 4th runs were 3,6 and 7 times longer than that of lst run respectively,the animals'survival times in hypobaric chamber and after cyanide intoxication were 26 and 2.6 times longer respctively than that of the control without exposure to hypoxia.These results indicute that the BALB/C mices tolerance to hypoxia is significantly increased through acute and repetitive exposure to hypoxia.

Key words: repeated hypoxia, hypobaric chamber, cyanide intoxication, BALB/C mice

中图分类号:

Q427

李凌;吕国蔚;安仰原. 急性重复缺氧对BALB/C小鼠缺氧耐受性的影响[J]. 首都医科大学学报, 1995, 16(4): 249-252.

Li Ling;Lu Guowei;An Yangyuan. Effects of Acute Repeated Hypoxia on Hypoxia Tolerance of BALB/C Mice[J]. Journal of Capital Medical University, 1995, 16(4): 249-252.

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