发酵培育冬虫夏草毒性研究Ⅰ．急性和亚慢性毒性研究

首都医科大学学报 ›› 1995, Vol. 16 ›› Issue (3): 198-203.

发酵培育冬虫夏草毒性研究Ⅰ．急性和亚慢性毒性研究

蒋保季, 孔祥环, 王惠琴, 尹学钧, 刘丽娟, 马忠杰, 王虹, 褚金花, 沈家芹, 张宏伟, 肖忠新

首都医学院预防医学系

收稿日期:1994-08-26 修回日期:1900-01-01 出版日期:1995-07-15 发布日期:1995-07-15

Toxicological Study of Cordyceps Sinensis Cultivated by Artificial Fermentation on Its Safety Evaluation Ⅰ. Acute and Sub-Chronic Toxicity Studies

Jiang Baoji, Kong Xianghuan, Wang Huiqin, Yin Xuejun, Liu Lijuan, Ma Zhongjie, Wang Hong

Department of Preventive Medicine, Capital Institute of Medicine

Received:1994-08-26 Revised:1900-01-01 Online:1995-07-15 Published:1995-07-15

摘要/Abstract

摘要： 对人工发酵培育冬虫夏草进行急性和亚慢性毒性研究。大、小鼠经口LD₅₀均大于10g/kg体重,亚慢性毒性研究(90d喂养试验)3个实验组动物生长发育正常,在试验第45d与第90d所作血液常规、血液生化、脏体比及病理学检查,3个实验组绝大多数检测项目与对照组未见显着性差异,极个别检测项目有显着性差异,但其差异无实际意义。研究表明人工发酵培育冬虫夏草毒理学是安全的。

关键词: 冬虫夏草, 毒理学, 亚慢性毒性

Abstract: Researches regarding the acute and sub-chronic toxicities of artificially fermented Cordyceps sinensis(AFCS) were conducted in this study. LD₅₀ of oral AFCSin both rat and mice were over 10 g/kg BW. After 90 d feeding of wealing rats ,all dosed animals grew and developed well and the average body weight of each dosed group was slightly higher than that of controls. The routine blood test, serum biochemical measurements, organ/body ratios and pathological examinations of major organs of rats were also determined in this study. The results showed that there was no difference between these indexes of dosed groups and that ofcontrols. The results demonstrate that AFSC is basically a toxicity-free and safe substance for rats.

Key words: Cordyceps sinensis, toxicology, sub-chronic toxicity

中图分类号:

R114

蒋保季;孔祥环;王惠琴;尹学钧;刘丽娟;马忠杰;王虹;褚金花;沈家芹;张宏伟;肖忠新. 发酵培育冬虫夏草毒性研究Ⅰ．急性和亚慢性毒性研究[J]. 首都医科大学学报, 1995, 16(3): 198-203.

Jiang Baoji;Kong Xianghuan;Wang Huiqin;Yin Xuejun;Liu Lijuan;Ma Zhongjie;Wang Hong. Toxicological Study of Cordyceps Sinensis Cultivated by Artificial Fermentation on Its Safety Evaluation Ⅰ. Acute and Sub-Chronic Toxicity Studies[J]. Journal of Capital Medical University, 1995, 16(3): 198-203.

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