首都医科大学学报 ›› 1996, Vol. 17 ›› Issue (4): 277-279.

• 论著 • 上一篇    下一篇

降钙素基因相关肽对心脏异位移植大鼠心律的影响

王蓉1, 李爽1, 叶翠飞2, 盛树力1, 乐效翚2   

  1. 1. 首都医科大学宣武医院老年病医疗研究中心多肽研究室;2. 宣武医院移植免疫研究室
  • 收稿日期:1995-12-11 修回日期:1900-01-01 出版日期:1996-10-15 发布日期:1996-10-15

The Effect of Calcitonin Gene Related Peptide on Arrhythmia Caused by Acontine in Heterotopic Heart Transplant Rats

Wang Rong1, Li Shuang1, Ye Cuifei2, Sheng Shuli1, Yue Xiaohui2   

  1. 1. Polypeptide Laboratory, Beijing Xuanwu Hospital , Affiliate of Capital University of Medical Sciences;2. Transplantation Immunology Laboratory
  • Received:1995-12-11 Revised:1900-01-01 Online:1996-10-15 Published:1996-10-15

摘要: 用乌头碱诱发心脏异位移植大鼠心律失常,给予降钙素基因相关肽(CGRP),观察其对心律的影响。结果:①心脏异位移植大鼠的自体和异体心脏对于CGRP的反应较正常大鼠迟钝,说明自体心脏和异体心脏中CGRP受体减少,此机理尚需探讨。②CGRP使1只大鼠异体心脏心电图出现P波,可能系CGRP对窦房结起刺激作用。

关键词: 降钙素基因相关肽, 乌头碱, 心脏异位移植, 心律失常

Abstract: Calcitonin gene related peptide(CGRP) is a most potent vasodilator.It plays an important role on arrhythmia.The purpose of this study was to observe the effects of CGRP on arrhythmia caused by aconitine in heterotopic heart transplant rats.The results showed : ①Both aceptor heart and transplanted heart had very weak reaction to CGRP.This suggested that the transplant heart has less CGRP receptors than normal heart.②CGRP can induce the appearance of P wave of electrocardiogram in one transplanted heart,this involved that CGRP may have a stimulation to sinus.

Key words: calcitonin gene related peptide, aconitine, heterotopic heart transplant, arRhythmia

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