急性心肌梗塞溶栓治疗中血浆心钠素与肾素系统的变化及意义

首都医科大学学报 ›› 1996, Vol. 17 ›› Issue (3): 211-214.

急性心肌梗塞溶栓治疗中血浆心钠素与肾素系统的变化及意义

华琦, 师树英, 秦俭, 何士大

首都医科大学宣武医院心血管内科

收稿日期:1900-01-01 修回日期:1995-07-20 出版日期:1996-07-15 发布日期:1996-07-15

Influence of Plasma Atrial Natriuretic Peptide, Plasma Renin Activity and Angiotensin Ⅱ on Venous Thrombolysis in Patients with Acute Myocardial Infarction

Hua Qi, Shi Shuying, Qin Jian, He Shida

Cardiovascular Department, Xuanwu Hospital, Affiliate of Capital University of Medical Sciences

Received:1900-01-01 Revised:1995-07-20 Online:1996-07-15 Published:1996-07-15

摘要/Abstract

摘要： 40例急性心肌梗塞(以下简称急性心梗)患者于静脉内溶栓前、溶栓2、24、72h及1周应用放免法检测血浆心钠素(ANP)、肾素(PRA)及血管紧张素Ⅱ(AngⅡ)水平,20例健康人为对照组。发现溶栓前心梗组较对照组ANP明显升高(P<0.01),2h达高峰(P<0.001),24、72h及1周有明显下降趋势,但仍较对照组增高(P均<0.05).其中26例再灌注指标明确者ANP2h较溶栓前明显升高(P<0.001).14例无再灌注指标者则无显着性差异。心梗组AngⅡ于2h达高峰,与对照组有显着性差异(P<0.01),24、72h及1周逐渐下降。PRA于2、24及72h亦均较对照组升高(P<0.05及0.01).不同部位及不同心功能状态的心梗患者血浆ANP水平无显着性差异。

关键词: 急性心肌梗塞, 静脉内溶栓治疗, 放射免疫分析法, 心钠素, 肾素-血管紧张素系统

Abstract: The concentration of atrial natriuretic peptide (ANP), plasma renin activity (PRA) and angiotensin Ⅱ (Ang Ⅱ) were measured in 40 patients with acute myocardial infarction at the time of admission, and the first 2, 24, 72 hours and one week after venous thrombolysis.20 normal subjects were control.It was found that ANP, PRA and Ang Ⅱ were significantly higher at admission in patients with AMI when compared to normal controls, and reached peak value at the first 2 hours after thrombolysis.ANP was significantly higher at the first 2 hours after thrombolysis than at admission in 28 patients with reperfusion,and there was no difference in 14 patients without reperfusion.There were no differences among different cardiac function and different region of infarction in patients with AMI in plasma ANP level.

Key words: acute myocardial infarction, venous thrombolysis, radioimmunoassay, atrial natriuretic peptide, renin angiotensin Ⅱ system

中图分类号:

R541.4

华琦;师树英;秦俭;何士大. 急性心肌梗塞溶栓治疗中血浆心钠素与肾素系统的变化及意义[J]. 首都医科大学学报, 1996, 17(3): 211-214.

Hua Qi;Shi Shuying;Qin Jian;He Shida. Influence of Plasma Atrial Natriuretic Peptide, Plasma Renin Activity and Angiotensin Ⅱ on Venous Thrombolysis in Patients with Acute Myocardial Infarction[J]. Journal of Capital Medical University, 1996, 17(3): 211-214.

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