分次大剂量照射对人脑恶性胶质瘤细胞BT325株的致死效应

首都医科大学学报 ›› 1996, Vol. 17 ›› Issue (3): 217-220.

分次大剂量照射对人脑恶性胶质瘤细胞BT₃₂₅株的致死效应

赵奇煌¹, 梁继军¹, 韩劲松¹, 柳辉², 韩彩和², 陈炳桓³, 郑玉书³, 杨炯达⁴

1. 北京市第四医院神经外科;2. 卫生部北京老年医学研究所;3. 北京市神经外科研究所;4. 北京天坛医院神经外科

收稿日期:1900-01-01 修回日期:1995-08-01 出版日期:1996-07-15 发布日期:1996-07-15

The Lethal Effects Analysis of BT₃₂₅ with Fractionated High Dose Irradiation

Zhan Qihuang¹, Liang Jijun¹, Han Jinsong¹, Liu Hui², Han Caihe², Chen Binhuan; Zheng Yushu³, Yang Jiongda³

1. Beijing Fourth Hospital;2. The Ministry of Health Beijing Gerontology Institute;3. Beijing Neurosurgical Institute;4. Department of Neurosurgery, Beijing Tiantan Hospital

Received:1900-01-01 Revised:1995-08-01 Online:1996-07-15 Published:1996-07-15

摘要/Abstract

摘要： 比较了分次大剂量和1次大剂量照射对BT₃₂₅细胞株的体外致死效应及细胞增殖的抑制作用。结果显示：分次大剂量(600cGy)与1次大剂量(4000cGy)照射有相同的致死效应,BT₃₂₅细胞数由照射前的5×10⁹/L,分别降为4.3×10⁷/L和4.0×10⁷/L(P>0.05);而对细胞增殖的抑制作用,前者明显优于后者,噻唑蓝OD值分别为0.006±0.001,0.160±0.020(P<0.01).这说明分次大剂量照射法在体外对肿瘤细胞有与1次大剂量照射同样的杀瘤效应和优于1次大剂量照射的抑制细胞增殖的作用。

关键词: 大剂量照射, BT325, 致死效应

Abstract: Campared between the FSRT and HSD for the lethal effects and the inhibiting action on BT325 in vitro.The results show FSRT' s lethal effects in same as HSD' s 5×10⁹～4.3×10⁷/L; 5×10⁹～4.0 ×10⁷/L respectively (P>0.05 ).As to the inhibiting action, the former is better than the latter, MTT OD 0.006± 0.001; 0.160 ±0.020, respectively (P<0.01 ).Demonstrate that the lethal effects of FSRT and HSD for tumor is same, the FSRT's tumor inhibiting action is better than the HSD's in vitro.

Key words: lethal effects, BT325 cell, high dose irradiation

中图分类号:

R739.41

赵奇煌;梁继军;韩劲松;柳辉;韩彩和;陈炳桓;郑玉书;杨炯达. 分次大剂量照射对人脑恶性胶质瘤细胞BT₃₂₅株的致死效应[J]. 首都医科大学学报, 1996, 17(3): 217-220.

Zhan Qihuang;Liang Jijun;Han Jinsong;Liu Hui;Han Caihe;Chen Binhuan;Zheng Yushu;Yang Jiongda. The Lethal Effects Analysis of BT₃₂₅ with Fractionated High Dose Irradiation[J]. Journal of Capital Medical University, 1996, 17(3): 217-220.

分次大剂量照射对人脑恶性胶质瘤细胞BT₃₂₅株的致死效应

The Lethal Effects Analysis of BT₃₂₅ with Fractionated High Dose Irradiation

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