突发性聋患者血浆内皮素-1和降钙素基因相关肽改变的观察

首都医科大学学报 ›› 1998, Vol. 19 ›› Issue (2): 168-170.

突发性聋患者血浆内皮素-1和降钙素基因相关肽改变的观察

王星宇¹, 孔锋¹, 张丽蓉¹, 李忠如¹, 艾厚喜², 盛树力²

1. 首都医科大学宣武医院耳鼻喉科;2. 首都医科大学宣武医院多肽研究室

收稿日期:1997-10-16 修回日期:1900-01-01 出版日期:1998-04-15 发布日期:1998-04-15

Investigation on Plasma Concentrations of ET-1 and CGRP in Sudden Deafness

Wang Xingyu¹, Kong Feng¹, Zhang Lirong¹, Li Zhongru Ai Houxi¹, Sheng Shuli²

1. Department of ENT, Xuanwu Hospital, Affiliate of Capital University of Medical Sciences;2. Polypepide Laboratory, Xuanwu Hospital, Affiliate of Capital University of Medical Scie

Received:1997-10-16 Revised:1900-01-01 Online:1998-04-15 Published:1998-04-15

摘要/Abstract

摘要： 为探讨突发性聋的发病机制,测定和比较了24例突发性聋病人治疗前后的血浆内皮素-1(ET-1)和降钙素基因相关肽(CGRP)含量的变化.发现:治疗有效组治疗前血浆ET-1水平明显高于治疗后(P<0.05),而CGRP水平则明显低于治疗后(P<0.01).提示:ET-1升高和CGRP降低可能是突发性耳聋的发病因素之一.

关键词: 突发性聋, 内皮素1, 降钙素基因相关肽

Abstract: In order to study the pathogenic mechanism of sudden deafness, the authors investigated and compared the plasma concentrations of ET-1 and CGRP in 24 cases of sudden deafness patients pre and post treatment. The result showsed: In the group in which hearing was clearly improved the concentration of ET-1 were significantly higher pre treatment than post treatment and the concentration of CGRP were much lower pre treatment than post treatment. The result indicated that high plasma concentration of ET-1 and low concentration of CGRP may act as the pathogenic factors predisposing occurrence of sudden deafness.

Key words: sudden deafness, ET-1, CGRP

中图分类号:

R764.437

王星宇;孔锋;张丽蓉;李忠如;艾厚喜;盛树力. 突发性聋患者血浆内皮素-1和降钙素基因相关肽改变的观察[J]. 首都医科大学学报, 1998, 19(2): 168-170.

Wang Xingyu;Kong Feng;Zhang Lirong;Li Zhongru Ai Houxi;Sheng Shuli. Investigation on Plasma Concentrations of ET-1 and CGRP in Sudden Deafness[J]. Journal of Capital Medical University, 1998, 19(2): 168-170.

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