幽门螺杆菌毒力菌株感染与胃十二指肠疾病的关系

首都医科大学学报 ›› 2000, Vol. 21 ›› Issue (3): 206-208.

幽门螺杆菌毒力菌株感染与胃十二指肠疾病的关系

朱玉群, 王燕斌, 李欣欣, 张磊, 杨昭徐

首都医科大学附属北京天坛医院消化内科

收稿日期:1999-08-17 修回日期:1900-01-01 出版日期:2000-07-15 发布日期:2000-07-15

Relationship between Specific HP Strain Infection with CagA Seropositive and Gastroduodenal Diseases

Zhu Yuqun, Wang Yanbin, Li Xinxin, Zhang Lei, Yang Zhaoxu

Division of Gastroenterology, Beijing Tiantan Hospital, Affiliate of Capital University of Medical Sciences

Received:1999-08-17 Revised:1900-01-01 Online:2000-07-15 Published:2000-07-15

摘要/Abstract

摘要： 应用间接ELISA法,测定1674例经胃镜检查患者的血清幽门螺杆菌(HP)细胞毒素相关基因A(CagA)抗体,探讨HP菌型差异与其致胃十二指肠疾病的关系。结果：疾病组血清CagA抗体检出率为49.70%,高于健康组的38%(P<0.05);活动期十二指肠溃疡(DU)的抗体检出率显着高于活动期胃溃疡(GU)、胃癌(GC)和慢性胃炎(CG)(P<0.01);活动性炎症的抗体检出率显着高于非活动性炎症(P<0.01).随CG炎症程度加重,抗体阳性率呈递增性增加(P<0.05,P<0.01);GC及各癌前病变抗CagA检出率与健康组比较无差异。提示：HP产毒菌感染与胃十二指肠粘膜炎症活动及损伤程度有关.

关键词: 幽门螺杆菌, 细胞毒素相关基因A, 胃十二指肠疾病

Abstract: In order to assess the relationship between different HP bacteria types and their pathogenicity,investigated 1 674 patients who underwent gastroscopy and 100 blood donors. HP infection was diagnosed by at least 2 positive results from PCR, histology (Giemsa staining), or rapid urease test. Serum CagA IgG antibodies were measured by ELISA. It was found that total prevalence of CagA seropositive was 49.70% in patients and 38% in controls (P<0.05). The frequency of CagA antibodies were significantly higher in DU cases than that of in GU,GC and CG ones(P<0.01). In active and severe degree of CG, anti-CagA presence was more common(P<0.01). However, no difference was found in anti-CagA positive rate among GC, CAG, IM, AH and normal groups. These data indicated that specific HP strain with CagA seropositive was associated with the degree of damages and active inflammation on gastroduodenal mucosa.

Key words: Helicobacter pylori, cytotoxin-associated gene A, gastroduodenal diseases

中图分类号:

朱玉群;王燕斌;李欣欣;张磊;杨昭徐. 幽门螺杆菌毒力菌株感染与胃十二指肠疾病的关系[J]. 首都医科大学学报, 2000, 21(3): 206-208.

Zhu Yuqun;Wang Yanbin;Li Xinxin;Zhang Lei;Yang Zhaoxu. Relationship between Specific HP Strain Infection with CagA Seropositive and Gastroduodenal Diseases[J]. Journal of Capital Medical University, 2000, 21(3): 206-208.

[1]	刘春涛, 苏珈仪, 旦增卓嘎, 伊比然恨, 卓玛, 张澍田. 西藏自治区藏族人群幽门螺杆菌毒力菌株分型与慢性胃炎及消化性溃疡的相关性研究[J]. 首都医科大学学报, 2022, 43(3): 463-468.
[2]	苏珈仪, 刘春涛, 王铁山, 李文坤, 杨奕, 武珊珊, 李鹏, 吴静. 血清幽门螺杆菌抗体分型检测与胃黏膜病变的相关性[J]. 首都医科大学学报, 2022, 43(2): 216-220.
[3]	董方, 陈东, 商建峰, 方微, 滕飞, 张睿祺. 门诊消化系统疾病患者幽门螺杆菌感染状况分析[J]. 首都医科大学学报, 2020, 41(3): 372-375.
[4]	王德昭, 王军, 李世敬, 陈步星. 幽门螺杆菌感染对植入药物洗脱支架急性冠状动脉综合征患者长期预后的影响[J]. 首都医科大学学报, 2016, 37(6): 746-752.
[5]	孙艳艳;王雅杰;康熙雄. 幽门螺杆菌实验室诊断研究进展[J]. 首都医科大学学报, 2007, 28(2): 185-188.
[6]	王玉兰;吴燕川;沙中芬. 幽门螺杆菌临床常用检测方法的比较[J]. 首都医科大学学报, 2006, 27(3): 408-409.
[7]	王瑶;王雁;袁申元;万小平. 幽门螺杆菌阳性溃疡病的远期疗效观察[J]. 首都医科大学学报, 1999, 20(2): 107-109.
[8]	朱玉群;杨昭徐. 老年人幽门螺旋杆菌相关性胃十二指肠疾病[J]. 首都医科大学学报, 1995, 16(3): 210-213.