北方汉族Grave病与HLA相关性研究

首都医科大学学报 ›› 2000, Vol. 21 ›› Issue (2): 122-124.

北方汉族Grave病与HLA相关性研究

鲁梅花, 邵文硕

首都医科大学宣武医院内分泌科

收稿日期:1999-06-20 修回日期:1900-01-01 出版日期:2000-04-15 发布日期:2000-04-15

The Study of Grave Disease Associated with HLA in Northern Han Chinese

Lu Meihua, Shao Wenshuo

Department of endocrine, Xuanwu Hospital, Affiliate of Capital University of Medical Sciences

Received:1999-06-20 Revised:1900-01-01 Online:2000-04-15 Published:2000-04-15

摘要/Abstract

摘要： 利用序列特异性寡核苷酸引物多聚酶链反应(PCR/SSP)的方法,对北方汉族42例Grave病患者及52例正常对照组的HLADR2、DR3的分布频率进行了分析。结果：Grave病患者组HLADR3抗原的频率明显高于正常对照组(P<0.05),相对危险度为3.84,而HLADR2抗原的频率在2组间无明显差异(P>0.05).提示：HLADR3与北方汉族Grave病的发病有相关性。

关键词: Grave病, 组织相容性白细胞抗原(HLA), 多聚酶链反应(PCR), 序列特异性寡核苷酸引物(SSP)

Abstract: Northern Han Chinese patients with Grave disease and 52 healthy controls were randomly chosen. Ploymerase chain reaction and sequence specific primer (PCR/SSP) were used to determine the frequency of HLA DR2 and DR3. The frequency of DR3 was increased in Grave disease patients, the relative risk (RR) was 3.84(P<0.05). The RR of DR2 was 1.16(P>0.05). The above results suggested that HLA DR3 is associated with Grave disease in Northern Han Chinese.

Key words: Grave disease, HLA, PCR, SSP

中图分类号:

R581.1

鲁梅花;邵文硕. 北方汉族Grave病与HLA相关性研究[J]. 首都医科大学学报, 2000, 21(2): 122-124.

Lu Meihua;Shao Wenshuo. The Study of Grave Disease Associated with HLA in Northern Han Chinese[J]. Journal of Capital Medical University, 2000, 21(2): 122-124.

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