Graves病患者骨代谢变化的早期检测

首都医科大学学报 ›› 1999, Vol. 20 ›› Issue (3): 186-188.

Graves病患者骨代谢变化的早期检测

任继平, 王雪, 田剑, 林愈之, 于湄

首都医科大学附属北京同仁医院内科

收稿日期:1998-11-12 修回日期:1900-01-01 出版日期:1999-07-15 发布日期:1999-07-15

Bone Metabolism Change in Graves Disease

Ren Jiping, Wang Xue, Tian Jian, Lin Yuzhi, Yu Mei

Department of Gastroenterology, Beijing Tongren Hospital, Affiliate of Capital University of Medical Sciences

Received:1998-11-12 Revised:1900-01-01 Online:1999-07-15 Published:1999-07-15

摘要/Abstract

摘要： 为探讨早期发现Graves病(简称GD)患者的骨代谢异常,对63例GD患者进行了尿脱氧吡啶啉(Dpd)、血清骨钙素(BGP)、碱性磷酸酶(AKP)、血钙、血磷及腰椎(L_2～4)、股骨上端骨密度(BMD)的测定。结果：GD组血BGP、尿Dpd均高于正常对照组(P<0.05);除≤40岁女性GD组的腰椎和股骨上端^{[股骨颈(NECK)、华氏三角(WARD)及股骨粗隆(TROCH)]}的BMD和>40岁女性GD组的WARDBMD外,其余各组腰椎及股骨上端的BMD均低于正常对照组(P<0.05).相关性分析：BGP、Dpd与FT4呈正相关(P<0.05),与病程无相关性,BGP与NECK、WARD呈负相关(P<0.05).结果提示：BMD、尿Dpd、血清BGP的测定可以早期发现GD患者的骨代谢异常,较传统方法更加特异和敏感。

关键词: Graves病, 骨密度, 血清骨钙素, 尿脱氧吡啶啉

Abstract: In order to learn the changes of bone metabolism in Graves disease early, urinary deoxypyridinoline(Dpd), serum bone GLA protein(BGP), alkaline phosphatase(AKP), serum calcium, phosphorus and bone mineral density of lumbar_2～4, upper femur of 63 patients with Graves disease were tested. The result showed serum BGP and urinary Dpd were higher than the controls (P<0.05). BMD of lumbar 2～4 and the upper femur were lower than the controls (P<0.05) except those female patients younger than forty years old and those of WARD in female patients older than forty years old. The correlation analysis showed that serum BGP and urinary Dpd were positive correlated with FT₄, but not with duration of illness, serum BGP was negative correlated with femur (NECK, WARD′s triangle) (P<0.05). The results suggested that the test of BMD, urinary Dpd and serum BGP could detect the abnormal changes of bone metabolism in Graves disease, these tests were more specific and sensitive than those traditional methods.

Key words: Graves disease, bone mineral density, serum bone GLA protein, urinary deoxypyridinoline

中图分类号:

R581.1

任继平;王雪;田剑;林愈之;于湄. Graves病患者骨代谢变化的早期检测[J]. 首都医科大学学报, 1999, 20(3): 186-188.

Ren Jiping;Wang Xue;Tian Jian;Lin Yuzhi;Yu Mei. Bone Metabolism Change in Graves Disease[J]. Journal of Capital Medical University, 1999, 20(3): 186-188.

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