128例50岁以下结直肠癌患者的临床特点及预后分析

doi:10.3969/j.issn.1006-7795.2019.01.024

摘要/Abstract

摘要： 目的探究50岁以下结直肠癌患者的临床特点，分析影响预后的因素，为临床医师提高对50岁以下结直肠癌的认识提供帮助。方法回顾性分析2005年1月1日至2012年12月31日于首都医科大学附属北京友谊医院行手术治疗的50岁以下结直肠癌患者的临床资料，并采集其术后随访信息。Kaplan-Meier法绘制生存曲线；Log-rank检验行单因素分析，将单因素分析中有意义的因素纳入多因素COX回归分析，判断影响预后的独立因素。结果在128例50岁以下的结直肠癌患者中，最常见的临床表现是便血、腹痛和排便习惯改变，黏液腺癌和印戒细胞癌的比例占25.8%，TNM分期Ⅲ期和Ⅳ期的比例占61.7%。多因素分析显示，根治性手术、癌结节与50岁以下结直肠癌患者的预后有关。结论 50岁以下结直肠癌患者的病理类型较差、TNM分期较晚，有癌结节的患者通常具有较差的预后，而根治性手术对提高50岁以下结直肠癌患者的预后有促进作用。

关键词: 结直肠癌, 年轻患者, 临床特点, 预后, 生存分析

Abstract: Objective To explore the clinical features of patients under 50 years old suffering from colorectal cancer and analyze the factors that influence the prognosis, so as to help clinicians to improve the understanding of patients under 50 years old suffering from colorectal cancer. Methods We retrospectively analyzed the clinical data of colorectal cancer patients under the age of 50 who received surgical treatment in our hospital from January 1st, 2005 to December 31st, 2012, and collected their postoperative follow-up information. The Kaplan-Meier method was used to draw the survival curve. The Log-rank test was used to the univariate analysis. Factors that were significant in the univariate analysis were included in the COX multivariate regression analysis to determine the independent factors that affected the prognosis. Results The most common clinical manifestations of patients under 50 years old with colorectal cancer were hematochezia and abdominal pain.The proportion of mucinous adenocarcinoma and signet ring cell carcinoma was 25.8%, and the ratio of TNM stage Ⅲ and IV was 61.7%. Multivariate analysis showed that radical operation,tumor deposits were associated with the prognosis of patients under 50 years old with colorectal cancer. Conclusion The patients under 50 years old with colorectal cancer have poor pathological types and late TNM stages. Patients with tumor deposits usually have a poorer prognosis, and radical surgery can improve the prognosis of patients under 50 years of age with colorectal cancer.

Key words: colorectal cancer, the young, clinical characteristics, prognosis, survival analysis

中图分类号:

徐谊, 赵晓牧, 李亚伦, 郭炜, 孙武青, 王今. 128例50岁以下结直肠癌患者的临床特点及预后分析[J]. 首都医科大学学报, 2019, 40(1): 136-142.

Xu Yi, Zhao Xiaomu, Li Yalun, Guo Wei, Sun Wuqing, Wang Jin. Clinical characteristics and prognosis of patients under 50 years old suffering from colorectal cancer: a retrospective analysis of 128 cases[J]. Journal of Capital Medical University, 2019, 40(1): 136-142.

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