首都医科大学学报 ›› 2025, Vol. 46 ›› Issue (5): 839-844.doi: 10.3969/j.issn.1006-7795.2025.05.012

• 基础研究 • 上一篇    下一篇

微型植入式盆底神经肌肉电刺激系统在不同频率下治疗大鼠压力性尿失禁的疗效对比

龙博鸿1,2, 李晨2, 邓函2, 孙浩瑜2, 廖利民2, 李兴1,2*   

  1. 1.温州医科大学附属第二医院育英儿童医院康复科，浙江温州 325035; 2.首都医科大学康复医学院中国康复研究中心泌尿外科，北京 100068
  • 收稿日期:2024-10-21 修回日期:2025-02-15 出版日期:2025-10-21 发布日期:2025-10-22
  • 通讯作者: 李兴 E-mail:lxcpums@126.com
  • 基金资助:
    北京市自然科学基金面上项目（7222235），中国康复研究中心研究项目（2021zx-11）。

Comparative efficacy of a miniature, implantable pelvic floor neuromuscular stimulation system at different frequencies for the treatment of stress urinary incontinence based on a rat model

Long Bohong 1,2, Li Chen 2, Deng Han 2, Sun Haoyu 2, Liao Limin 2, Li Xing 1,2*   

  1. 1. Department of Rehabilitation, The Second Affiliated Hospital and Yuying Childrens Hospital of Wenzhou Medical University, Wenzhou 325035，Zhejiang Province，China; 2. Department of Urology, Rehabilitation School of Capital Medical University, China Rehabilitation Research Center, Beijing 100068，China
  • Received:2024-10-21 Revised:2025-02-15 Online:2025-10-21 Published:2025-10-22
  • Supported by:
    This study was supported by Natural Science Foundation of Beijing（7222235），Research Project of China Rehabilitation Research Center（2021zx-11）.

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摘要： 目的  探究不同频率的盆底电刺激（pelvic floor electrical stimulation, PFES）对大鼠压力性尿失禁（stress urinary incontinence, SUI）的疗效。方法  将20只雌性未育的Sprague-Dawley大鼠采用数字表法随机分为6、15、30和50 Hz组。所有大鼠行阴道扩张（vaginal dilatation, VD）以模拟产后SUI。VD后1周，通过喷嚏试验确定造模是否成功，若喷嚏试验阳性则为造模成功。在造模成功的大鼠盆底肌内植入微型、无线盆底电刺激器，分别用6、15、30和50Hz的频率对每组大鼠行连续2周的PFES治疗。通过膀胱压力测定（cystometrograms, CMGs）测量所有大鼠VD前、VD后1周以及刺激2周后的漏尿点压力（leak point pressure, LPP）进行对比。结果  VD后1周各组大鼠LPP显著降低（P＜0.001）。与VD后1周相比，在6、15、30和50Hz四种不同频率下进行连续2周的PFES后，各组大鼠的LPP又显著升高（P＜0.001），且达到基线水平（P＞0.05）。在各组大鼠的组间对比中，其LPP在基线值、VD后1周及刺激2周后差异均无统计学意义（P＞0.05）。结论  在目前探索的几种刺激频率中，6Hz可能是PFES的较为合适的选择。后续仍需进一步研究以评估更多频率及PFES的长期疗效。

关键词: 压力性尿失禁, 盆底电刺激, 频率, 神经肌肉刺激, 植入式, 无线

Abstract: Objective  To investigate the comparative efficacy of different frequencies of pelvic floor electrical stimulation (PFES) on stress urinary incontinence (SUI) in rats.Methods  Twenty female Sprague-Dawley rats were randomly divided into 6, 15, 30 and 50 Hz group by random number table method. All rats underwent vaginal dilatation (VD) to simulate postpartum SUI. One week after VD, the sneeze test was conducted to determine whether the modeling was successful. If the sneeze test was positive, the modeling was successful. The miniature and wireless electric pelvic floor stimulator were implanted into the pelvic floor muscle of the modeled rats, and PFES were treated for 2 weeks in each group at the rates of 6, 15, 30 and 50 Hz, respectively. The Leak point pressure (LPP) of all rats before VD, 1 week after VD and 2 weeks after stimulation were measured by cystometrograms (CMGs) for comparison.Results  LPP was significantly reduced in all groups of rats after VD 1 week (P < 0.001). Compared with after VD 1 week, after two consecutive weeks of PFES at four different frequencies of 6, 15, 30 and 50 Hz, LPP was again significantly increased (P < 0.001) and reached the baseline level (P > 0.05) in all groups of rats. In the between-group comparison of the rats in each group, there was no significant difference in their LPP at baseline value, after VD 1 week and after stimulation 2 weeks (P > 0.05).Conclusion  The present study suggests that of the several stimulation frequencies explored so far, 6 Hz may be a more appropriate choice for PFES. Further studies are still needed to evaluate more frequencies and the long-term efficacy of PFES.

Key words: stress urinary incontinence, pelvic floor electrical stimulation, frequency, neuromuscular stimulation, implantable, Wireless

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