关键词: 妊娠期高血糖, 二甲双胍, 后代远期健康, 神经发育, 生殖功能, 代谢

Abstract: Hyperglycemia in pregnancy is a disorder of carbohydrate metabolism that occurs during pregnancy and is associated with a variety of adverse pregnancy outcomes and an increased risk of long-term maternal and infant metabolic syndrome. Pregnant women with hyperglycemia who do not achieve the blood glucose standard despite lifestyle interventions should receive hypoglycemic drug treatment. Metformin, a classic hypoglycemic drug, has received increasing attention in its application during pregnancy. Current studies show that it has a certain effect on controlling maternal blood glucose, yet its impact on the long-term health of offspring is controversial. This review summarizes the effects of metformin exposure in utero during pregnancy on the obesity, blood pressure, lipid metabolism, endocrine system, reproductive health, and nervous system of offspring, as well as the viewpoints of guidelines from various countries on the application of metformin during pregnancy, thereby facilitating clinicians’ comprehensive understanding of the safety and rationality of metformin application during pregnancy.

Key words: hyperglycemia during pregnancy,  , metformin, offspring long-term health, neurodevelopment, reproductive function, metabolism