HOX基因在脊髓室管膜肿瘤中的研究进展

doi:10.3969/j.issn.1006-7795.2026.03.015

首都医科大学学报 ›› 2026, Vol. 47 ›› Issue (3): 527-531.doi: 10.3969/j.issn.1006-7795.2026.03.015

HOX基因在脊髓室管膜肿瘤中的研究进展

汪皖婷,王雷明,滕梁红^*

首都医科大学宣武医院病理科，北京 100053

收稿日期:2026-01-21 修回日期:2026-03-25 出版日期:2026-06-21 发布日期:2026-06-26
通讯作者: 滕梁红 E-mail:tenglianghong@xwhosp.org
基金资助:
北京市临床重点专科建设项目。

Research progress of HOX genes in spinal ependymal tumors

Wang Wanting, Wang Leiming, Teng Lianghong^*

Department of Pathology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China

Received:2026-01-21 Revised:2026-03-25 Online:2026-06-21 Published:2026-06-26
Supported by:
This study was supported by Beijing Municipal Key Clinical Specialty Construction Project.

摘要/Abstract

摘要： HOX基因是一类高度保守的同源盒基因家族，在胚胎发育、细胞分化和组织稳态中发挥关键作用，其异常表达与多种肿瘤的发生、发展及预后密切相关。越来越多的证据表明，HOX基因的失调可能在脊髓室管膜肿瘤的发生、发展及侵袭性中起重要作用。本文综述了HOX基因的调控机制、在脊髓室管膜肿瘤中的表达模式及其潜在的临床价值，并探讨了未来研究方向。

关键词: HOX基因, 脊髓室管膜瘤, 黏液乳头型室管膜瘤, 调控机制, 表达特征, 临床价值

Abstract: HOX genes constitute a highly conserved family of homeobox genes, which play a crucial role in embryonic development, cell differentiation, and tissue homeostasis. Abnormal expression of these genes is closely related to the occurrence, development, and prognosis of various tumors. Increasing evidence suggests that the dysregulation of HOX genes may play an important role in the occurrence, development, and invasiveness of spinal meningeal tumors. This article reviews the regulatory mechanisms of HOX genes, their expression patterns in spinal meningeal tumors, and their potential clinical value. Finally, this review outlines directions for future research.

Key words: HOX genes, spinal cord ependymoma, myxopapillary ependymoma, regulatory mechanism, expression features, clinical value

中图分类号:

R365，R361，R363，R364.7

汪皖婷, 王雷明, 滕梁红. HOX基因在脊髓室管膜肿瘤中的研究进展[J]. 首都医科大学学报, 2026, 47(3): 527-531.

Wang Wanting, Wang Leiming, Teng Lianghong. Research progress of HOX genes in spinal ependymal tumors[J]. Journal of Capital Medical University, 2026, 47(3): 527-531.

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HOX基因在脊髓室管膜肿瘤中的研究进展

Research progress of HOX genes in spinal ependymal tumors

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