关键词: 妊娠期急性脂肪肝, 肝衰竭, 弥漫性血管内凝血, 黄疸

Abstract: Objective To detect the clinical characteristics of acute fatty liver in pregnancy. Methods Retrospective analysis was performed on 9 cases delivered in Beijing Obstetrics and Gynecology Hospital during the recent 6 years. Results Acute fatty liver in pregnancy occured in the third trimester, the first symptom of the 9 cases was the digestive tract symptom, such as nausea, vomiting, malaise, etc. The damage of liver, kidney and coagulatory system would appear within short time. Liver function abnormality included hypoalbuminemia and elevated hepatic aminotransferase levels(ALT, AST), total bilirubin and direct bilirubin. Kidney function abnormality included elevated BUN and creatinine. Clotting dysfunction included prolonged prothrombin time, low platelet and disseminated intravascular coagulation(DIC). The mortality of pregnant women with this syndrome was 11.1%, and the mortality of neonates was 16.7%. Conclusion The outcome of pregnant women and neonates was closely related to the course of the illness and therapy. Early diagnosis, termination of pregnancy in time, and prevention of DIC would improve the outcome of pregnant women and neonates.

Key words: acute fatty liver of pregnancy, liver failure, disseminated intravascular coagulation, jaundice