转化医学与中国微创外科的发展

doi:10.3969/j.issn.1006-7795.2015.05.027

首都医科大学学报 ›› 2015, Vol. 36 ›› Issue (5): 800-804.doi: 10.3969/j.issn.1006-7795.2015.05.027

转化医学与中国微创外科的发展

李俊, 郭伟, 张军, 张忠涛

首都医科大学附属北京友谊医院普外科肿瘤侵袭和转移机制研究北京市重点实验室国家消化系统疾病临床研究中心, 北京 100050

收稿日期:2014-01-02 出版日期:2015-10-21 发布日期:2015-10-20

Translational medicine and the development of minimally invasive surgery in China

Li Jun, Guo Wei, Zhang Jun, Zhang Zhongtao

Department of General Surgery, Beijing Key Laboratory of Cancer Invasion and Metastasis Research & National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

Received:2014-01-02 Online:2015-10-21 Published:2015-10-20
Contact: 张忠涛 E-mail:zhangzht@medmail.com.cn

摘要/Abstract

摘要： 转化医学(translational medicine,TM)的概念于1992年提出,它的核心是一门将医学生物学基础研究成果迅速有效的转化为可在临床实际应用的理论、技术、方法和药物的科学。近年基础医学研究投入不断提高,但能应用到临床的成果却甚少,如何提高基础医学研究成果的转化率,受到世界范围内广泛关注,转化医学因此应孕而生。纵观世界微创外科的发展史,亦是实验科学与临床科学不断促进和发展的过程。中国微创外科起步较晚,但经过中国微创外科前辈们的努力,从基础研究转化到临床应用并逐步摸索出自己的经验,提高自身在国际上的影响力。总的来看,基础研究成果丰硕,但真正能转化为临床实践并得到验证却很少,如何提高转化医学的转化率是全世界面临的难题。本文简要综述了转化医学的概念与发展,转化医学在中国微创外科中的应用及面临的问题。

关键词: 转化医学, 中国微创外科, 经自然孔道内镜外科, 单孔腹腔镜技术

Abstract: Translational medicine (TM) was first introduced in 1992. The core objective of TM is to translate basic scientific findings into therapeutic interventions for patients. TM can increase the understanding of important disease processes. In recent years, the investment in basic medical research has been increasing, but very few results can benefit clinical practice. To prevent basic and clinical medicine being disjointed and fragmented, TM is urgently needed. In worldwide, the development history of minimally invasive surgery (MIS) is also the process of collaborative development between basic medicine and clinical medicine. China adopted the minimally invasive surgery later than the western countries. However, through the early TM efforts of Chinese academics, Chinese MIS is building up a momentum and starts to impact MIS field worldwide. The most important issue at this time is how we improve the conversion rate of basic medicine to clinical medicine. Here, we briefly review the applications and difficulties of TM in MIS, especially in China.

Key words: translational medicine, Chinese minimally invasive surgery, natural orifice translumenal endoscopic surgery, laparoendoscopic single site surgery

中图分类号:

R605

李俊, 郭伟, 张军, 张忠涛. 转化医学与中国微创外科的发展[J]. 首都医科大学学报, 2015, 36(5): 800-804.

Li Jun, Guo Wei, Zhang Jun, Zhang Zhongtao. Translational medicine and the development of minimally invasive surgery in China[J]. Journal of Capital Medical University, 2015, 36(5): 800-804.

参考文献

[1] The National Institutes of Health (NIH) Clinical Center [EB/OL]. [2014-01-02]. http://www.cc.nih.gov/ccc/btb/#slide_text. 2013.
[2] Van Dongen G A, Ussi A E, de Man F H, et al. EATRIS, a European initiative to boost translational biomedical research[J]. Am J Nucl Med Mol Imaging, 2013, 3(2):166-174.
[3] Wang X D, Wang E, Francesco M M. Translational medicine is developing in China: a new venue for collaboration[J]. J Transl Med, 2011, 9: 3.
[4] The University of Chicago Medicine [EB/OL]. [2014-01-02]. http://www.uchospitals.edu/specialties/minisurgery/mis.html. 2013.
[5] Schollmeyer T, Soyinka A S, Schollmeyer M, et al. Georg Kelling (1866-1945): the root of modern day minimal invasive surgery. A forgotten legend?[J]. Arch Gynecol Obstet, 2007, 276(5): 505-509.
[6] 郑民华. 腹腔镜技术的现状与展望[J]. 中国实用外科杂志, 2010, 30(3):164-166.
[7] Orenstein S B, Elliott H L, Reines L A, et al. Advantages of the hand-assisted versus the open approach to elective colectomies[J]. Surg Endosc, 2011, 25(5):1364-1368.
[8] Guo W, Zhang Z T. Laparoscopic surgery in the mainland of China[J]. Chin Med J:Engl, 2009,122(19):2226-2228.
[9] 郑民华.中国腹腔镜外科的现状与进展[J]. 中华腔镜外科杂志: 电子版, 2010, 3(1): 1-6.
[10] Pini G, Porpiglia F, Micali S, et al. Minilaparoscopy, needlescopy and microlaparoscopy: decreasing invasiveness, maintaining the standard laparoscopic approach[J]. Arch Esp Urol, 2012, 65(3):366-383.
[11] Kalloo A N, Singh V K, Jagannath S B, et al. Flexible transgastric peritoneoscopy: a novel approach to diagnostic and therapeutic interventions in the peritoneal cavity[J]. Gastrointest Endosc, 2004, 60(1):114-117.
[12] Kantsevoy S V, Jagannath S B, Niiyama H, et al. Endoscopic gastrojejunostomy with survival in a porcine model[J]. Gastrointest Endosc, 2005, 62(2):287-292.
[13] Wagh M S, Merrifield B F, Thompson C C. Endoscopic transgastric abdominal exploration and organ resection: initial experience in a porcine model[J]. Clin Gastroenterol Hepatol, 2005, 3(9):892-896.
[14] Swanstrom L L, Kozarek R, Pasricha P J, et al. Development of a new access device for transgastric surgery[J]. J Gastrointest Surg, 2005, 9(8):1129-1136.
[15] Park P O, Bergström M, Ikeda K, et al. Experimental studies of transgastric gallbladder surgery: cholecystectomy and cholecystogastric anastomosis (videos)[J]. Gastrointest Endosc, 2005, 61(4):601-606.
[16] Reddy D N, Rao G V. Transgastric approach to the peritoneal cavity: are we on the right track?[J]. Gastrointest Endosc, 2005, 61(4):601-606.
[17] 周晓娜,张忠涛. 经脐单孔腹腔镜外科技术应用现状和展望[J]. 中国实用外科杂志, 2009, 29(1):42-43.
[18] Guo W, Zhang Z T, Han W, et al. The application status and prospects of transumbilical laparoendoscopic single site surgery[J]. Chin Med J: Engl, 2008, 121(23):2463-2464.
[19] Cai J, Zhang Z T, Sun J, et al. Transumbilical single-incision laparoscopic resection of ileocecal junction for benign disease: first report of two cases[J]. Surg Innov, 2011, 18(2):189-192.

转化医学与中国微创外科的发展

Translational medicine and the development of minimally invasive surgery in China

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