关键词: 医院真菌, 药物敏感试验, 菌群分布

Abstract: Objective To understand common fungal species and antifungal drug resistance in our hospital and to provide important evidences for rational use of antifungal agents in clinical practice. Methods We performed fungal culture for clinically collected specimens from January 2014 to December 2015, and used CHROMagar Candida chromogenic medium and API 20C AUX yeast identification kit to identify fungal species. ATB Fungus 3 susceptibility kits were used to test drug susceptibility. At last, we counted the composition of fungal species and sensitive rates of 5 kinds of antifungal drugs. Results We obtained a total of 399 strains of fungi. Urine was the main sample of clinical specimen and Candida albicans were the main strain (188 strains, accounting for 47.1%) in Candida. In filamentous fungi, Aspergillus fumigatus were the main strain (25 stains, accounting for 6.3%). The sensitivity of Candida albicans to antifungal drugs was more than 95%, but the sensitivity of Candida glabrata to azole was relatively low and only 65.1% for fluconazole. Aspergillus had a high sensitivity to amphotericin B, itraconazole and voriconazole. Conclusion Candida albicans was the main hospital fungal infection and amphotericin B and 5-flucytosine had high antifungal activity against this fungus. Candida glabrata had a higher resistance to azoles and clinically reasonable use of antifungal drugs according to the results of drug susceptibility is very important.

Key words: hospital fungi, drug susceptibility test, pathogens distribution