关键词: 重症监护病房, 院内获得性感染, 病原菌分布, 肺炎克雷伯杆菌

Abstract: Objective The study was conducted to analyze the pathogen division and drug resistance of nosocomial infection in intensive care unit (ICU), and to provide advice for the clinical application of antibiotics.Methods A retrospective survey was conducted to analyze the results of pathogens and drug susceptibility test in the patients hospitalized in ICU Beijing Friendship Hospital,Capital Medical University and contracting hospital infection during the period from January 1, 2015 to December 31, 2016.Results A total of 363 cases were reported during 2 years, out of which 271 strains were isolated. The top 5 pathogens were Klebsiella pneumoniae (16.97%), Acinetobacter baumannii (13.28%), Pseudomonas aeruginosa (12.18%), Enterococcus faecium (10.7%), and Staphylococcus aureus (5.9%).The top three infection sites were lower respiratory tract (55.7%), blood (17.6%),abdominal pelvic tissue(9.9%). The incidence of Klebsiella pneumonia in 2016 was significantly higher than that in 2015 (P<0.05).Conclusion During the study period, the most common part of nosocomial infection in ICU was in the lower respiratory tract. The incidence of Klebsiella pneumoniae increased significantly suggesting that antibiotics should be used reasonably, because most of Klebsiella pneumoniae were multi-drug resistant.

Key words: intensive care unit, hospital acquired infection, pathogen distribution, klebsiella pneumoniae