首都医科大学学报 ›› 2024, Vol. 45 ›› Issue (5): 923-927.doi: 10.3969/j.issn.1006-7795.2024.05.027

• 拉斯克奖 • 上一篇    下一篇

华裔科学家陈志坚发现感知DNA免疫监控的cGAS-STING信号通路——2024年拉斯克奖基础医学研究奖

周妍,吴巍*   

  1. 首都医科大学基础医学院生物化学与分子生物学系,北京  100069
  • 收稿日期:2024-09-24 出版日期:2024-10-21 发布日期:2024-10-18
  • 通讯作者: 吴巍 E-mail:weiwu207@ccmu.edu.cn

Ethenic Chinese scientist Chen Zhijian  discovers the cGAS-STING signaling pathway that senses DNA for immune surveillance——the 2024  Lasker Basic Medical Research Awards

Zhou Yan, Wu Wei*   

  1. Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China
  • Received:2024-09-24 Online:2024-10-21 Published:2024-10-18

摘要: 北京时间2024年9月19日,生物医学领域重要奖项拉斯克奖(The Lasker Award)揭晓,华人学者陈志坚博士(德克萨斯大学西南医学中心)因发现感知自身及外源DNA的环鸟嘌呤-腺嘌呤核苷酸合成酶[cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) synthase, cGAS],阐明了DNA如何刺激免疫和炎症反应的分子机制荣获基础医学研究奖。

关键词: 拉斯克奖, 环鸟嘌呤-腺嘌呤核苷酸合成酶, 环鸟苷酸-腺苷酸, 免疫疗法, DNA感受器

Abstract: On September 19, 2024 by Beijing Times, the 2024 Albert Lasker Basic Medical Research Award, an important biomedical award, honors a biochemist, Zhijian“James”Chen (UT Southwestern Medical Center, University of Texas) for the discovery of the cGAS enzyme that senses foreign and self DNA, which solves the mystery of how DNA stimulates immune and inflammatory responses.

Key words: The Lasker Award, cGAS, cGAMP, immunotherapy, DNA sensor

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