从分子积木到材料宇宙：金属有机框架赋能药物研发——2025年诺贝尔化学奖

doi:10.3969/j.issn.1006-7795.2025.06.026

首都医科大学学报 ›› 2025, Vol. 46 ›› Issue (6): 1157-1165.doi: 10.3969/j.issn.1006-7795.2025.06.026

从分子积木到材料宇宙：金属有机框架赋能药物研发——2025年诺贝尔化学奖

禄甜，张霁颐，马文阔，王玉记^*

首都医科大学药学院药物化学系内源式预防药物教育部工程研究中心多肽及小分子药物北京市重点实验室, 北京 100069

收稿日期:2025-10-28 修回日期:2025-10-30 出版日期:2025-12-21 发布日期:2025-12-19
通讯作者: 王玉记 E-mail:ccmuwyj@126.com
基金资助:
北京市科学技术委员会、中关村科技园区管理委员会项目（Z241100009024044），北京市创新医学研究组织科研计划项目（CX23YZ06）。

From molecular building blocks to the materials: metal-organic frameworks facilitate drug discovery——2025 Nobel Prize in Chemistry

Lu Tian, Zhang Jiyi, Ma Wenkuo, Wang Yuji ^*

Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Capital Medical University； Engineering Research Center of Endogenous Prophylactic of Ministry of Education ； Beijing Major Laboratory of Peptide and Small Molecular Drugs, Beijing 100069, China

Received:2025-10-28 Revised:2025-10-30 Online:2025-12-21 Published:2025-12-19
Supported by:
This study was supported by Beijing Municipal Science & Technology Commission, Administrative Commission of Zhongguancun Science Park (Z241100009024044)， Beijing Under the CIMR Organized Scientific Research Program (CX23YZ06).

摘要/Abstract

摘要： 北京时间2025年10月8日，瑞典皇家科学院宣布，将2025年诺贝尔化学奖授予日本京都大学北川进（Susumu Kitagawa）、澳大利亚墨尔本大学理查德·罗布森（Richard Robson）与美国加州大学伯克利分校奥马尔·亚吉（Omar M. Yaghi），以表彰他们为开发金属有机框架（metal-organic frameworks,MOFs）所作出的开创性贡献。

关键词: 诺贝尔化学奖, 金属有机框架, 多孔晶体材料, 药物研发, 药物递送, 诊疗一体化

Abstract: On October 8, 2025, Beijing time, The Royal Swedish Academy of Sciences announced that the 2025 Nobel Prize in Chemistry has been awarded to Susumu Kitagawa from Kyoto University, Japan; Richard Robson from University of Melbourne, Australia; and Omar M. Yaghi from University of California, Berkeley, USA. The award recognizes their pioneering contributions to the development of metal-organic frameworks (MOFs).

Key words: Nobel Prize in Chemistry, metal-organic frameworks, porous crystal materials, drug development, drug delivery, diagnosis and treatment integration

中图分类号:

禄甜, 张霁颐, 马文阔, 王玉记. 从分子积木到材料宇宙：金属有机框架赋能药物研发——2025年诺贝尔化学奖[J]. 首都医科大学学报, 2025, 46(6): 1157-1165.

Lu Tian, Zhang Jiyi, Ma Wenkuo, Wang Yuji . From molecular building blocks to the materials: metal-organic frameworks facilitate drug discovery——2025 Nobel Prize in Chemistry[J]. Journal of Capital Medical University, 2025, 46(6): 1157-1165.

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从分子积木到材料宇宙：金属有机框架赋能药物研发——2025年诺贝尔化学奖

From molecular building blocks to the materials: metal-organic frameworks facilitate drug discovery——2025 Nobel Prize in Chemistry

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