首都医科大学学报 ›› 1985, Vol. 6 ›› Issue (3): 191-194.

• 论著 • 上一篇    下一篇

在北京地区发现的异常血红蛋白——Hb Q Thailand(α74(EF3)Asp-His)

李天潢1, 倪雪亭1, 姚淑萍1, 汤青1, 王秀英1, 陈松森2, 杨克恭2, 贾佩臣2, 梁植权2, J. B. Willson3, T. H. J. Huisman3   

  1. 1. 北京友谊医院;2. 中国医学科学院基础医学研究所生物化学及分子生物学研究室;3. 美国乔治亚医学院细胞和分子生物学系蛋白质化学实验室
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:1985-07-15 发布日期:1985-07-15

A Hemoglobin Variant Found in Beijing——Hb Q Thailand (α74 (EF3) Asp-His)

Li Tianhuang1   

  • Received:1900-01-01 Revised:1900-01-01 Online:1985-07-15 Published:1985-07-15

摘要: 1981年9月,我们用醋酸纤维素薄膜电泳法对我院义务献血员进行异常血红蛋白普查时,发现一例慢速异常血红蛋白,位于HbA与HbA2之间,相当于Q组。采集先证者血样进行化学结构分析,证明为HbQThailand。 1958年,Valla等首先在一居住在新加坡的中国人家庭中发现了HbQ复合HbH病,当时未进行结构分析。随后在我国台湾(5)、泰国(6)和日本(7)相继发现,命名为HbG Thaich—ung[α74(EF3)Asp→His]或HbQ Thailand。曾氏在我国大陆首次报道,至今国内已发现多例,多在南方(8)。在我国北方尚未见报道。

Abstract: In 1981, an electrophoretically slow moving hemoglobin variant was found by cellulose a cetate electrophoresis among the healthy people in Beijing. This a bnormal zone migrated between Hb A and Hb A2 and occupied a position in the Q group. Structure studies demonstrated that this homoglobin variant was Hb Q Thailand. Valla et al first reported Hb Q Thailand combined with Hb H in a chinese family of singa pore in 1958 without performing any structure analysis. This variant was subsequently reported in Thaiwan, Thailand, and Japan, and was named Hb G Thaichung (α74 (EF3) Asp→His) or Hb Q Thailand. Zheng first reported in main land of China. Up to now, many of this variant have been reported in the south, but has never been reported hitherto in the north.