氧化苦参碱对小鼠肝微粒体药物代谢酶的诱导作用

首都医科大学学报 ›› 1987, Vol. 8 ›› Issue (1): 23-26.

氧化苦参碱对小鼠肝微粒体药物代谢酶的诱导作用

袁寀, 吕式琪, 姚娴

首都医学院药理教研室

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:1987-01-15 发布日期:1987-01-15

Inducing Role of Oxymatrine on the Hepatic Microsomal Drug-metabolism Enzyme in Mice

Yuan Cai, Lü Shiqi, Yao Xian

Department of Pharmcaology

Received:1900-01-01 Revised:1900-01-01 Online:1987-01-15 Published:1987-01-15

摘要/Abstract

摘要： 氧化苦参碱是自中药苦参中提取的一种生物碱,本文就其对小鼠肝微粒体药物代谢酶的影响进行了探讨。结果表明,氧化苦参碱(100mg/kg)能缩短小鼠戊比妥钠睡眠时间,提高肝微粒体细胞色素P-450含量并增强乙基吗啡N-脱甲基酶对硝基茴香醚O-脱甲基酶和苯并芘羟化酶的的活性,形态上使肝细胞滑面内质网增生。以上结果说明,氧化苦参碱是细胞色素P-450的诱导剂。

关键词: 细胞色素 P-450, 氧化苦碱, 药物代谢酶

Abstract: The effect of Oxymatrine(OMT),isolated from Sophora flavescens Ait,on the hepatic microsomal drug-metabolism enzyme have been investigated.It was found that the content of cytochrome P-450 (P-450),the ethylmorphine N-demethylase,the p-nitroanisole O-demethylase and the benzo(a)pyrene hydroxylase activities were significantly increased in OMT(100mg/kg)-pretreated mice.The proliferation of smooth endoplamic reticulum of liver cells was also stimulated by OMT.The results indicated that Oxymatrine is a inducer of P-450.

Key words: Cytochrome P-450, Oxymatrine, Drug-metabolism enzyme

袁寀;吕式琪;姚娴. 氧化苦参碱对小鼠肝微粒体药物代谢酶的诱导作用[J]. 首都医科大学学报, 1987, 8(1): 23-26.

Yuan Cai;Lü Shiqi;Yao Xian. Inducing Role of Oxymatrine on the Hepatic Microsomal Drug-metabolism Enzyme in Mice[J]. Journal of Capital Medical University, 1987, 8(1): 23-26.

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