甲状腺机能亢进的病因学研究

首都医科大学学报 ›› 1987, Vol. 8 ›› Issue (1): 39-43.

甲状腺机能亢进的病因学研究

陈哲生¹, 李毅民², 李龄风³, 朱琳³, 刘英琴³, 卢辉章⁴, 周继盛⁴

1. 首都医学院微生物学教研室;2. 中国医科院卫生学校;3. 首都医学院组织学教研室;4. 宣武医院外科

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:1987-01-15 发布日期:1987-01-15

The Investigation on Etiology of Grave's Disease

Chen Zhesheng¹

Department of Microbiology

Received:1900-01-01 Revised:1900-01-01 Online:1987-01-15 Published:1987-01-15

摘要/Abstract

摘要： 对15例甲亢病人甲状腺进行病理和免疫组化的研究。病理切片观察为典型甲亢病理变化,免疫组化证实其中6例有淋巴滤泡,并在淋巴滤泡中可见为酶标记IgG着色的淋巴细胞。对国际标准品LATS—B和国内提取LATS—天津两种甲状腺刺激自身抗体,进行一系列免疫学试验,实验结果证明LATS—B为IgG的多克隆免疫球蛋白,LATS—国内不是单一IgG,尚含有IgM。经ELISA试验首次证实神经节苷脂Ⅱ、Ⅳ和Ⅴ型都能与上述两种Tsaab结合,且Ⅳ型与LATS—B结合较好。

关键词: 甲状腺刺激抗体, 长效促甲状腺素, 神经节苷脂, 酶联免疫吸附试验

Abstract: The thyroids of 15 patients in Grave's disease have been examined with immunohistochemistry.Thyroid of Grave's disease has typical variation in pathology.6 eases are positive with lymphoid follicle. The lymphocytes in the follicles have been marked by the enzyme labeled IgG.Two Tsaabs(LATS—B and LATS Tianjin)have been tested by serial immunoassay.LATS—B is the polyclonal immunoglobulin of IgG.LATS-Tianjin is not unitary IgG,also with IgM.By the ELISA,evidenced that the Gangliosides (Ⅱ,IV,Vtype)all combined with two Tassbs,IVtype with LATS—B is better than other.

Key words: thyroid—stimulating bodies(TSABS), long acting thyroid stimulator (LATS), gangliosi des(Gg), ellzyme—linked oimmunsorbent assay(ELISA)

陈哲生;李毅民;李龄风;朱琳;刘英琴;卢辉章;周继盛. 甲状腺机能亢进的病因学研究[J]. 首都医科大学学报, 1987, 8(1): 39-43.

Chen Zhesheng. The Investigation on Etiology of Grave's Disease[J]. Journal of Capital Medical University, 1987, 8(1): 39-43.

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