与肿瘤相关的胎盘蛋白在胎盘绒毛组织中的定位和在肿瘤细胞上的检出

首都医科大学学报 ›› 1987, Vol. 8 ›› Issue (3): 181-184.

与肿瘤相关的胎盘蛋白在胎盘绒毛组织中的定位和在肿瘤细胞上的检出

曹祖华¹, 黄恕¹, 陈仁¹, 吴位育²

1. 首都医学院微生物学教研室;2. 首都医学院病理解剖学教研室

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:1987-07-15 发布日期:1987-07-15

The Localization of the Tumor-associated Placental Proteins in Human Placental Tissue and Detection in Parcinoma Pells

Cao Zuhua¹

Department of Microbiology

Received:1900-01-01 Revised:1900-01-01 Online:1987-07-15 Published:1987-07-15

摘要/Abstract

摘要： 用免疫酶组化方法对胎盘蛋白(PP)进行细胞学定位研究发现,与肿瘤相关的PP存在于胎盘绒毛组织合胞滋养层细胞的浆膜上。同时,在体外培养的肿瘤细胞株(肝癌细胞和胃癌细胞)中也存在着能与PP抗体起反应的抗原成分.本文对上述结果的意义进行了讨论。

关键词: 胎盘蛋白, 磁养层细胞, 肿瘤相关抗原

Abstract: The sections of human placenta were examined for the localization of the tumor-associated placental proteins(PP)by using mean of an indirect,peroxidase-labeled antibody procedure. Placental tissue section that were exposed to the antisera of the PPshowed a marked staining of the trophoblast plasma membrane. Additionally,the specific antisera of the PPalso stained the human liver carcinoma cell line(SMMC-7721)and the gastic carcinoma cell lines(MGC-803,Kato-111),suggesting these cell lines synthesize the proteins that similar to PPantigenically.

Key words: placental protein, trophoblast, tumor-associated antigen

曹祖华;黄恕;陈仁;吴位育. 与肿瘤相关的胎盘蛋白在胎盘绒毛组织中的定位和在肿瘤细胞上的检出[J]. 首都医科大学学报, 1987, 8(3): 181-184.

Cao Zuhua. The Localization of the Tumor-associated Placental Proteins in Human Placental Tissue and Detection in Parcinoma Pells[J]. Journal of Capital Medical University, 1987, 8(3): 181-184.