先天性心脏间隔缺损的肺血管病的形态定量法研究

首都医科大学学报 ›› 1987, Vol. 8 ›› Issue (4): 257-263.

先天性心脏间隔缺损的肺血管病的形态定量法研究

方健秋, 郑国芬

首都医学院病理解剖学教研室

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:1987-10-15 发布日期:1987-10-15

The Study of Pulmonary Vascular Disease in Congenital Cardiac Septal Defect by the Quantitative Morphometric Method

Fang Jianqiu, Zheng Guofen

Department of Pathology

Received:1900-01-01 Revised:1900-01-01 Online:1987-10-15 Published:1987-10-15

摘要/Abstract

摘要： 本文采用形态定量测定方法对61例正常及37例先天性心脏间隔缺损的尸检肺组织的肺血管结构进行了研究。结果表明,早期肺血管病变形态定量特征为:〈1〉肺动脉肌性化增加,即周围肺小动脉异常肌性伸延及肌性肺动脉中膜增厚;〈2〉周围肌性与部分肌性肺动脉密度增加;〈3〉肺细叶内小动脉直径减小。严重病变时,肺肌性动脉中膜萎缩变薄;动脉密度减少。本文观测到先心病新生儿期存在着持续性胎儿型肌性中膜厚壁现象,为左向右分流型先心病生后肺阻力不下降或延迟下降,提供了组织学根据。

关键词: 形态定量测定方法, 肺血管病, 先天性心脏间隔缺损

Abstract: By the quantitative morphometrie method,pulmonary vascular structure was studied on the lungs of 61 normal subjects and 37 cases who died from a congenital cardiac septal defect.The results showed that early pulmonary vascular changes were:(1)The increase of pulmonary arterial muscularity—a abnormal extension of muscle into peripheral arteries and an increased medial wall thickness of the normal muscular alteries,(2) The increase of density of pulmonary muscular and partially muscular arteries,(3)The reduction of the intraaeinar arterial size.Advanced pulmonary vascular changes were the reduction of the medial wall thickness and the decrease of the density of pulmonary muscular and partially muscular arteries. The persistence of the thick arterial wall of fetal life in neonate of congenital cardiac septal defect were observed and provided the histological evidence for the delaged postnatal fall of resistance and persistent fetal circulation in congenital cardiac septal defect with left to right shunt.

Key words: quantitative morphometric method, pulmonary vascular disease, congenital cardiac septal defect

方健秋;郑国芬. 先天性心脏间隔缺损的肺血管病的形态定量法研究[J]. 首都医科大学学报, 1987, 8(4): 257-263.

Fang Jianqiu;Zheng Guofen. The Study of Pulmonary Vascular Disease in Congenital Cardiac Septal Defect by the Quantitative Morphometric Method[J]. Journal of Capital Medical University, 1987, 8(4): 257-263.