首都医科大学学报 ›› 1988, Vol. 9 ›› Issue (4): 254-257.

• 论著 • 上一篇    下一篇

用免疫组织化学方法鉴别异位妊娠与正常妊娠

诸定寿1, Dean L. Moyer2   

  1. 1. 首都医学院组织胚胎学教研室;2. 美国南加州大学医学院女子医院病理系
  • 收稿日期:1988-04-01 修回日期:1900-01-01 出版日期:1988-10-15 发布日期:1988-10-15

The Differentiation Ectopic Pregnancy and Normal Pregnancy by Immunohistochemical Assay

Zhu Dingshou1, L. Moyer2   

  1. 1. Department of Histology and Embryology, Capital Institute of medicine;2. Department of Pathology, Women's Hospital, School of Medicine, Medical Center, University of Southern California
  • Received:1988-04-01 Revised:1900-01-01 Online:1988-10-15 Published:1988-10-15

摘要: 对57例内膜刮出组织和宫内流出组织均未检出绒毛膜绒毛。用抗血清标记绒毛滋养层的人绒毛膜促性腺激素(HCG)、人胎盘催乳素(HPL)和妊娠特异糖蛋白(SPI),结果18例被标记,37例未被标记。临床证明未被标记的37例为异位妊娠。表明用激素标记子宫内膜可提高异位妊娠的诊断率。

关键词: 宫外孕诊断, 免疫组织化学, 合休细胞滋养层, 人绒毛膜促性腺激素, 人胎盘催乳素, 人妊娠特异精蛋白

Abstract: Immunohistochemical demonstration of placental hormones and pregnancy specific β-1-glycoprotein of villus is a usful tool in the differentiation of normal pregnancy and ectopic pregnancy. There were 57 samples in the study. We did not find chorionic villus in all endometrium curetting or spontaneously passed tissue. Using specific antiserum we detected human chorionic gonadotropin (HCG), (human) placental lactogen (HPL) and pregnancy specific β-1-glycoprotein (PSI) in the trophoblast of villus. The 18 of normal pregnancy specimens were marked with HCG, HPL and PSI. The other 37 specimens which were ectopic pregnancy were not marked. Therefore, we concluded that the use of these hormones marks in endometrium specimens significatly increased the precision of the diagnosis for the ectopic pregnancy.

Key words: ectopic pregnancy diagnosis, immunohistochemistry