人早孕蜕膜组织中神经递质与神经肽含量的研究

首都医科大学学报 ›› 1989, Vol. 10 ›› Issue (1): 40-45.

人早孕蜕膜组织中神经递质与神经肽含量的研究

姚军¹, 张理崇², 王红², 沈卫斌²

1. 首都医学院宣武医院计划生育研究室;2. 中科院动物所生殖生物学实验室

收稿日期:1988-07-04 修回日期:1900-01-01 出版日期:1989-01-15 发布日期:1989-01-15

Studies on the Neurotransmitters and Neuropeptides of Decidua in the Human Early Pregnancy

Yao Jun¹

Department of Genecology, XuanWu Hospital, Capital Institutl of Medicine

Received:1988-07-04 Revised:1900-01-01 Online:1989-01-15 Published:1989-01-15

摘要/Abstract

摘要： 于吸刮术时收集月经周期增殖期和分泌期的子宫内膜组织及妊娠6～11周的新鲜壁蜕膜组织。用高压液相色谱-电化学检测及放射免疫法对38例子宫内膜及70例早孕壁蜕膜组织中的各种神经递质、神经肽含量进行测定。证实早孕蜕膜组织富含神经递质、神经肽。其中DA、DOPAC显著高于子宫内膜中的量(P<0.05),且随妊娠时间的延长含量逐渐升高,β-EP及LH-RH的含量也显著高于子宫内膜组织(p<0.05),但随妊娠时间的延长含量逐渐下降。这一初步结果表明蜕膜组织可以合成神经递质、神经肽,其意义有待进一步深入研究。

关键词: 增埴期, 分泌期, 壁蜕膜, 早孕, 神经递质, 神经肽

Abstract: Fresh human endometrium in the follicular and luteal phases of the menstrual cycle and wall decidual tissues at 6-11 weeks of gestation were collected by suction curettage. Content of the different kindes of neurotransmitters and neuropeptides in the endometrial and decidual tissues were tested using HPLC technique and RIA, respectively. It was found that the contents of neurotransmitters and neuropeptides in the decidua were very abandant, and DA, DOPAC. β- EP and LH-RH of them in the decidua appeared significantly higher than those in the endometrium (P<0.05). The contents of DA and DOPAC in the decidua increased gradually with the prolongation of the gestation weeks (p<0.05). On the contrary,β-EP and LH-RH showed decrease (p<0.05). These preliminary results suggest that the decidua synthesizes not only β-EP, LH-RH, but also neurotransmitters.

Key words: follicular phase, luteal phase, wall decidua, early pregnancy, enurotransmitters, neuropiptides

姚军;张理崇;王红;沈卫斌. 人早孕蜕膜组织中神经递质与神经肽含量的研究[J]. 首都医科大学学报, 1989, 10(1): 40-45.

Yao Jun. Studies on the Neurotransmitters and Neuropeptides of Decidua in the Human Early Pregnancy[J]. Journal of Capital Medical University, 1989, 10(1): 40-45.

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