银耳多糖对红细胞膜保护作用初探

首都医科大学学报 ›› 1992, Vol. 13 ›› Issue (2): 100-104.

银耳多糖对红细胞膜保护作用初探

曾昭晖, 宋晓红, 黄沛力

首都医学院实验中心

收稿日期:1992-02-26 修回日期:1900-01-01 出版日期:1992-04-15 发布日期:1992-04-15

Studies on the Protection Action of Tremella Fuciformis Polysaccharide on Erythrocyte Membrane

Zeng Zhaohui, Song Xiaohong, Huang Peili

Laboratorial Centre, Capital Institute of Medicine

Received:1992-02-26 Revised:1900-01-01 Online:1992-04-15 Published:1992-04-15

摘要/Abstract

摘要： 用邻苯三酚在碱性条件下自氧化产生的超氧阴离子自由基(O₂^·-)对红细胞膜的过氧化损伤作用为研究模型,探讨银耳多糖对红细胞膜的保护作用。结果表明,银耳多糖对红细胞膜有抗氧化作用,表现为膜蛋白交联作用减少;膜流动性趋于正常,红细胞溶血率降低。通过邻苯三酚在碱性条件下自氧化的试验,提示银耳多糖对邻苯三酚自氯化反应没有抑制作用。

关键词: 银耳多糖, 红细胞膜, 超氧阴离子自由基

Abstract: The present paper discusses the role of tremella fucitormis Polysaccharide(TFS) in pro-tection of erythrocyte membranes from damage by superoxide anion O₂^·- generated from auto-oxidation of pyrogallie acid(pA) at pH 8.4. The addition of TFS to pyrogallic acid and ery-thocyte membranes system caussed a decrease in high molecular weight protein polymers (HMP), an increase in fluidity and a depression in hemolysis rate of the red cells, Showing TFS has antiperoxidation effect on erythrocyte membranes. However no inhibition of TFS on auto-oxidative reaction of PA was shown when the auto-oxidation experiment was under taken under basic condition.

Key words: tremella fuciformis polysaccharide, erythrocyte membrane, superoxide anion, lipoperoxide

中图分类号:

Q592.1

曾昭晖;宋晓红;黄沛力. 银耳多糖对红细胞膜保护作用初探[J]. 首都医科大学学报, 1992, 13(2): 100-104.

Zeng Zhaohui;Song Xiaohong;Huang Peili. Studies on the Protection Action of Tremella Fuciformis Polysaccharide on Erythrocyte Membrane[J]. Journal of Capital Medical University, 1992, 13(2): 100-104.

[1]	阎淑莲;张锦楠. 中药对红细胞膜流动性影响的研究[J]. 首都医科大学学报, 1997, 18(1): 18-20.
[2]	何士大;于仲元;张叔诚;刘成立;徐宝钢;汪家瑞. 原发性高血压患者红细胞膜Ca²⁺—ATP酶活性的初步观察[J]. 首都医科大学学报, 1987, 8(4): 283-285.