关键词: 化学发光, 肾移植, 吞噬功能, 排斥, 透析

Abstract: The changes of phagocytic function in phagocytes were estimated by chemiluminescence (CL). in renal transplanted patients prior and after their surgery. Forty-seven patients re-ceived renal transplantation for 1 to 8 years, (thirty-seven with normal renal function and 10 with abnormal renal function), were randomly chosen to be the subjects for estimating the peak CL/10³ leucocytes, the state of pre-activated phagocytes in vivo(basal) and the opsonic activity of plasma, comparing with 15 hemodialysis patients who had not received transplan-tation, 13 renal transplanted patients whose transplanted kidney had been removed due to se-vere rejection, and 38 normal controls. The peak CL/10³ leucocytes of receptors with good renal function had no apparent difference compared with that of normal control, while The peak CL/10³ leucocytes of the receptors with abnormal renal function significantby differed from the value of control, dialysis patients without transplantation and patients whose trans-planted kidney removed (P<0. 05). In comparing with the controls, the backgrand level in patients obviously increased while no difference was shown in the peak time. These results show that after renal transplantation the increasments of phagocytic function and the pre-ac-tivated state in vivo predict the occurence of renal function failure and rejrction. This study suggest that is useful in diagnosing the rejection of transplant in clincal examination.

Key words: chemiluminescence(CL), ranal transplant, phagocytic function, rejection, diulysis