首都医科大学学报 ›› 1992, Vol. 13 ›› Issue (4): 252-255.

• 论著 • 上一篇    下一篇

结蛋白抗体制备及其在肌源性组织肿瘤诊断中的应用

王蓬文, 郑国芬, 董小黎, 王珏   

  1. 首都医学院病理解剖学教研室
  • 收稿日期:1991-10-07 修回日期:1900-01-01 出版日期:1992-10-15 发布日期:1992-10-15

The Preparation of Anti-desmin Serum and Its Use in the Diagnosis of Myosarcomas

Wang Pengwen, Zheng Guofeng, Dong Xiaoli, Wang Jue   

  1. Department of Pathology, Capital Institute of Medicine
  • Received:1991-10-07 Revised:1900-01-01 Online:1992-10-15 Published:1992-10-15

摘要: 用自制的高效价兔抗鸡结蛋白(Desmin)抗血清,对26例横纹肌肉瘤(RMS),7例平滑肌肉瘤(LMS),11例其他肿瘤及多种正常组织进行免疫过氧化物酶-抗过氧化物酶(PAP)染色。结果表明:Desmin是肌源性组织及其肿瘤特有标志。26例RMS中25例阳性,7例LMS中5例阳性,其他肿瘤及除肌源性组织外的正常组织均阴性。该抗血清对病理诊断肌源性组织肿瘤有一定价值。

关键词: 结蛋白抗体, 免疫组化, 肌源性组织肿瘤

Abstract: A rabbit antiserum directed against desmin purified from chicken gizzard, was used to immun-ohistochemical by stain tumor tissues of 26 RMS, 7 LMS, 11 other tumors and vari-ety of normal tissues.Twenty five cases of RMS and 5 cases of LMS were shown to be posi-tive.Only myocyte originated tissues were positive to anti-desmin serum, while all other nor-mal tissues were negitive.Thus the desmin can be regarded as a specific marker of myocytes and is useful in the diagnosis of myosarcomas.

Key words: antidesmin serum, immunohistochemistry, myosarcomas

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