十二指肠溃疡疾病中胃泌素与幽门螺旋杆菌感染的相关性研究

首都医科大学学报 ›› 1993, Vol. 14 ›› Issue (2): 128-131.

十二指肠溃疡疾病中胃泌素与幽门螺旋杆菌感染的相关性研究

梁丕霞¹, 杨昭徐¹, 陈晶晶², 庄韬², 张绍东³, 盛树力³

1. 首都医学院附属北京天坛医院内科消化组;2. 中国预防医科院流行病学微生物研究所;3. 北京市神经外科研究所

收稿日期:1992-04-17 修回日期:1900-01-01 出版日期:1993-04-15 发布日期:1993-04-15

The Studies on the Links between Release of the Serum Gastrin and Helicobacter Pylori Infection in Duoderal Ulcer

Liang Peixia¹, Yang Zhaoxu¹, Chen Jingjing², Zhuang Tao², Zhang Shaodong³, Sheng Shuli³

1. Beijing Tiantan Hospital, Capital Institute of Medicine;2. Chinese Academy of Prophylactic Medical Sciences;3. Beijing Neurosurgical Institute

Received:1992-04-17 Revised:1900-01-01 Online:1993-04-15 Published:1993-04-15

摘要/Abstract

摘要： 于治疗前后对十二指肠溃疡(DU)病人74例(男46例,女28例.平均年龄40.5±21.5)。均经胃镜胃粘膜活检幽门螺旋菌(HP)培养、血清抗 HP 抗体、病理组织学染色检查 HP、血清胃泌素检查.结果表明;①HP 感染者抗 HPIgG 滴度及血清胃泌素水平明显增高.②抗菌治疗清除 HP 后,血清胃泌素及抗 HP 抗体滴度均有明显下降.提示 HP 感染致病与血清胃泌素释放增加有关,联合应用血清胃泌素检查和 HP 血清学检查可以作为胃镜检查前 HP 感染病例筛选和治疗后 HP 清除的客观指标。

关键词: 十二指肠溃疡, 幽门螺旋杆菌, 血清胃泌素, 酶联免疫吸附实验

Abstract: The multiple approaches to determine HP infection were studied before and after the treatment of duodenal ulcer(DU).The approaches included the culture of HP in antral biop-sies;the Giemsa staining of histological sections;urease test and serum anti-HP IgG antibo-dies measurement with and ELISA technique;the serium gastrin(RIA) was simultaneously controled.The results show that there was significnat rise in anti-HP IgG titre and level of serum gastrin,and after the clearance of HP,the level of serum gastrin and anti-HP antibody titres significantly decreased.The results supported the hypothesis that HP infection causes DU as well as the increase of serum gastrin release.Both serology and the gastrin measure-ment may be helpful in assessmont of the effect of clinical treatment and epidenilogical stud-ies.

Key words: duodenal ulcer, helicobacter pylori, serium gastrin, Ig antibody

中图分类号:

R573.1

梁丕霞;杨昭徐;陈晶晶;庄韬;张绍东;盛树力. 十二指肠溃疡疾病中胃泌素与幽门螺旋杆菌感染的相关性研究[J]. 首都医科大学学报, 1993, 14(2): 128-131.

Liang Peixia;Yang Zhaoxu;Chen Jingjing;Zhuang Tao;Zhang Shaodong;Sheng Shuli. The Studies on the Links between Release of the Serum Gastrin and Helicobacter Pylori Infection in Duoderal Ulcer[J]. Journal of Capital Medical University, 1993, 14(2): 128-131.

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