首都医科大学学报 ›› 1993, Vol. 14 ›› Issue (3): 171-174.

• 论著 • 上一篇    下一篇

女性外阴尖锐湿疣及湿疣样病变组织中人类乳头瘤病毒DNA的检测

单爱琳1, 高建平1, 高天祥1, 余秀梅2, 宋学红2, 唐小奈2   

  1. 1. 首都医学院电镜室;2. 首都医学院附属北京红十字朝阳医院
  • 收稿日期:1992-03-19 修回日期:1900-01-01 出版日期:1993-07-15 发布日期:1993-07-15

The Detection of DNA Type of Human Papilloma Virus in Condylomata Acuminata and Condylomalike Vulvar Lesions

Shan Ailin1, Gao Jianping1, Gao Tianxing1, Yu Xiumei2, Song Xuehong2, Tang Xiaonai2   

  1. 1. Department of Electron Microscope, Capital Institute of Medicine;2. Beijing Red Cross Chaoyang Hospital, Capital Institute of Medicine
  • Received:1992-03-19 Revised:1900-01-01 Online:1993-07-15 Published:1993-07-15

摘要:

用生物素和32P-人类乳头瘤病毒 HPV11、HPV16和 HPV18型 DNA 探针,以斑点和 SouthernBlot 杂交方法检测了49例北京地区女性外阴尖锐湿疣和湿疣样病变组织中 HPV DNA。在24例尖锐湿疣组织中,HPV DNA 阳性者为18例(75%);其中 HPV11 DNA 阳性者16例,占阳性例数的88.9%;HPV16 DNA 阳性者2例,占阳性例数的11.1%;没有发现 HPV18 DNA 阳性者.25例湿疣样病变组织中,8例含有 HPV DNA(32%),全为 HPV11型。本文对湿疣样病变与 HPV 感染的关系,外阴部尖锐湿疣的分型及诊断标准进行了初步探讨。

关键词: 尖锐湿疣, 人类乳头瘤病毒, 核酸杂交, 湿疣样病变

Abstract:

49 cases(24 condylomata acuminata,25 condylomalike vulvar lesions)are examined for HPV DNA type by Dot and Southern Blot hybridization.75% of condylomata acuminata is positive,and 88.9% of positive cases is HPV11 type while 11.1% is of HPV 16 type.Com-paring with condylomata acuminata,only 32% of 25 condylomalike vulvar lesions contains HPV type 11 DNA.The classification,diagnostic criteria of condylomata acuminata as well as eitiology of condylomalike vulvar lesions are discussed.

Key words: condylomata acuminata, human papilloma virus, hybridization of nucleic acid, condylomalike vulvar lesion

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