首都医科大学学报 ›› 1993, Vol. 14 ›› Issue (4): 287-290.

• 论著 • 上一篇    下一篇

168例肿瘤S-100蛋白免疫组织化学研究

张菊英, 朱昌仁   

  1. 首都医学院附属北京天坛医院病理科
  • 收稿日期:1992-07-04 修回日期:1900-01-01 出版日期:1993-10-15 发布日期:1993-10-15

Immunohistochemical Study of S-100 Protein Distribution in Neoplastic Tissues

Zhang Juying, Zhu Changren   

  1. Beijing Tiantan Hospital, Capital Institute of Medicine
  • Received:1992-07-04 Revised:1900-01-01 Online:1993-10-15 Published:1993-10-15

摘要: 应用S-100蛋白多克隆抗体和单克隆抗体过氧化物酶抗过氧化物酶免疫组织化学染色法(PAP)对S-100蛋白在168例全身多种肿瘤细胞中的分布进行了系统研究。结果表明,S-100蛋白不仅存在于胶质瘤、神经鞘瘤、神经纤维瘤、外伤性神经瘤、恶性神经鞘瘤和“蝾螈”瘤中,而且还分布于黑色素痣、黑色素瘤、脂肪肉瘤、软骨瘤、软骨肉瘤、涎腺和乳腺肿瘤中。此外,发现支气管腺癌、甲状腺嗜酸性腺瘤、甲状腺髓样癌和胆管细胞癌S-100蛋白阳性。讨论了S-100蛋白在肿瘤鉴别诊断中的意义.

关键词: S-100蛋白, 免疫组织化学, 肿瘤

Abstract: A systematic immunohistochemical investigation of S-100 protein was performed on 168 cases of various neoplastic tissues with anti-S-100 protein polyclonal and monoclonal antibodies.S-100 protein was observed in glioma,Schwannoma,neurofibroma,traumatic neuroma,malignant Schwannoma and“Triton”tumor.S-100 protein was also detected in pigmented nevus,melanoma,liposarcoma,chondrosarcoma and salivary gland tumors.Espe-cially,we have demonstrated S-100 protein in eosinophilic adenoma and medullary carcinoma of thyroid gland,adenocarcinoma of bile duct and bronchiolar adenocarcinoma.The value of S-100 protein on tumor dignosis was discussed.

Key words: S-100 protein, immunohistochemistry, tumor

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