丙基硫氧嘧啶改善甲亢患者心脏及内分泌功能的疗效及意义

首都医科大学学报 ›› 1994, Vol. 15 ›› Issue (1): 41-44.

丙基硫氧嘧啶改善甲亢患者心脏及内分泌功能的疗效及意义

华琦, 续大田, 汪家瑞

首都医学院宣武医院内科

收稿日期:1992-11-30 修回日期:1900-01-01 出版日期:1994-01-15 发布日期:1994-01-15

Effects of Propylthiouracil on Improving Heart and Endocrine Functions in Patients with Hyperthyroidism and Its Clinical Significance

Hua Qi, Xu Datian, Wang Jiarui

Xuanwu Hospital, Capital Institute of Medicine

Received:1992-11-30 Revised:1900-01-01 Online:1994-01-15 Published:1994-01-15

摘要/Abstract

摘要： 13例初诊甲亢患者于应用丙基硫氧嘧啶治疗前、治疗3个月及6个月时超声心动图检测心功能并用放射免疫分析法检测血浆心钠素(ANP)、肾素活性(PRA)、血管紧张素Ⅱ(AngⅡ)及血清甲状腺激素(TT₃、TT₄)水平.治疗后心率下降(P<0.001),体重增加(P<0.001),心输出量及心指数下降(P<0.05).各瓣膜区流速减慢(P<0.05),TT₃、TT₄恢复正常.随高动力性循环状态改善,血浆ANP水平明显下降(P<0.01).AngⅡ及PRA明显升高(P<0.01及0.001).提示丙基硫氧嘧啶能有效改善甲亢患者的心脏功能及内分泌功能.

关键词: 甲状腺功能亢进症, 丙基硫氧嘧啶, 心脏功能试验, 心钠素, 肾素－血管紧张素系统

Abstract: Thirteen patients with newly diagnosed hyperthyroidism were treated with propylthiouracil.Heart function and plasma atrial natriuretic peptide(ANP), plasma renin activity(PRA)and angiotension Ⅱ(Ang Ⅱ)levels of the patients were measured by echocardiography and specific radioimmunoassay, before treatment and during treatment at third month and sixth month. After treatment, heart rate of the patients were significantly decreased(P<0.001), body weight were increased(P<0.01), cardiac output,cardiac index,peak flow velocity of mitral valve, aortic valve and main pulmonary artery were decreased(P<0.05),thyroid hormone became normal. With hyperdynamic circulating state improving, plasma ANP level was significantly decreased(P<0.01)and Ang Ⅱ and PRA were increased(P<0. 01). These results suggest that propylthiouracil is an effective drug in improving heart and endocrine functions in patients with hyperthyroidism.

Key words: hyperthyroidism, propylthiouracil, heart function tests, atrial natriuretic peptide, renin-angiotensin system

中图分类号:

华琦;续大田;汪家瑞. 丙基硫氧嘧啶改善甲亢患者心脏及内分泌功能的疗效及意义[J]. 首都医科大学学报, 1994, 15(1): 41-44.

Hua Qi;Xu Datian;Wang Jiarui. Effects of Propylthiouracil on Improving Heart and Endocrine Functions in Patients with Hyperthyroidism and Its Clinical Significance[J]. Journal of Capital Medical University, 1994, 15(1): 41-44.

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