液化石油气燃烧颗粒物对小鼠骨髓细胞微核率的影响

首都医科大学学报 ›› 1994, Vol. 15 ›› Issue (3): 191-193.

液化石油气燃烧颗粒物对小鼠骨髓细胞微核率的影响

尹学钧¹, 李永顺¹, 孔祥环¹, 刘君卓²

1. 首都医学院环境卫生学教研室;2. 北京医科大学环境卫生学教研室

收稿日期:1993-06-07 修回日期:1900-01-01 出版日期:1994-07-15 发布日期:1994-07-15

Induction of Micronuclei in Mice Treated with Extracts of Particulates from Liquefied Petroleum Gas(LPG)Combustion

Yin Xuejun¹, Li Yongshun¹, Kong Xianghuan¹, Liu Junzhuo²

1. Departmentof Environmental Health, Capital Institute of Medicine;2. Department of Environmental Health, Beijing Medical University

Received:1993-06-07 Revised:1900-01-01 Online:1994-07-15 Published:1994-07-15

摘要/Abstract

摘要： 对液化石油气燃烧颗粒物诱发小鼠骨髓细胞微核进行了研究.结果表明,提取物剂量在100～400mg/kg之间,微核率由10.9‰升至28.8‰,呈明显的剂量-反应关系,各剂量组与对照组比较均具极显着性差异(P<0.01).说明液化石油气燃烧颗粒物在体内可产生明显的遗传毒性作用,这种作用可能是该颗粒物诱发肺癌的机制之一.

关键词: 液化石油气, 颗粒物, 微核试验, 室内空气污染

Abstract: Methylene chloride extracts of particulates from LPG combustion appliance were studied in micronucleus test in mice.The test was carried out with Kunming mice treated with the extracts at 100,200 and 400 mg/kg(ip,twice).A significant dose-dependent increase in MNPCE was clearly observed in all dose groups compared to that of the control(P<0.01).The extracts also had a marked cytotoxic effect on bone marrow as indicated by a significant reduction in PCE/NCE ratio with the dose(P<0.05).Therefore,it was considered that the extracts might be clastogen or spindle poison that was mutagenic in vivo and might be potential carcinogenic.

Key words: liquefied petroleum gas, particulate, micronucleus test, indoor air pollution

中图分类号:

R126.8

尹学钧;李永顺;孔祥环;刘君卓. 液化石油气燃烧颗粒物对小鼠骨髓细胞微核率的影响[J]. 首都医科大学学报, 1994, 15(3): 191-193.

Yin Xuejun;Li Yongshun;Kong Xianghuan;Liu Junzhuo. Induction of Micronuclei in Mice Treated with Extracts of Particulates from Liquefied Petroleum Gas(LPG)Combustion[J]. Journal of Capital Medical University, 1994, 15(3): 191-193.

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