分枝杆菌多糖对小鼠造血功能的影响

首都医科大学学报 ›› 1994, Vol. 15 ›› Issue (3): 197-199.

分枝杆菌多糖对小鼠造血功能的影响

迟永春¹, 万方¹, 徐梅¹, 陈仁²

1. 中日友好临床医学研究所;2. 首都医学院微生物学教研室

收稿日期:1992-12-20 修回日期:1900-01-01 出版日期:1994-07-15 发布日期:1994-07-15

Effects of MPS on the Hemopoietic Function of Mice

Chi Yongchun¹, Wan Fang¹, Xu Mei¹, Chen Ren²

1. Institute of Clinical Sciences, China-Japan Friendship Hospital;2. Department of Microbiology, Capital Institute of Medicine

Received:1992-12-20 Revised:1900-01-01 Online:1994-07-15 Published:1994-07-15

摘要/Abstract

摘要： 观察了分枝杆菌多糖(MPS)对环磷酰胺抑制BALB/c小鼠骨髓作用的影响.结果表明:给予CPA使小鼠骨髓GM-CFU抑制约30%左右.1.0mg/kg的MPS对GM-CFU有促进作用(第1批实验CPA对照组316.5±34.6,实验1组454.5±19.1,P<0.05;第2批实验CPA对照组208.7±43.7,实验2组437.8±54.1,P<0.02);而0.15mg/kgMPS无促进作用.在0.15和1.0mg/kg剂量下,小鼠血清GM-CSF活性水平明显提高;0.15和1.0mg/kgMPS可分别刺激小鼠每0.1mL血清产生500U和850UGM-CSF.分析认为MPS与日本的Z-100活性水平相当,这些作用可能通过激活单核或T细胞而间接产生.

关键词: 分枝杆菌多糖, 小鼠骨髓造血祖细胞, 血清造血刺激因子

Abstract: We studied the effects of Mycobacterial polysaccharides(MPS)on the suppression function of cyclophosphamide to BALB/C mice bone marrow.The results showed that 1.0 mg/kg of MPS had enhance effects on the GM-CFU(control-1,316.5±34.6,MPS group,454.5±19.1 ,P<0.05;control-2,208.7±43.7,MPS group,437.8±54.1, P<0.02). However,in 0.15 mg/ kg and 1.0 mg/kg of MPS,the levels of GM-CSF activity in sera of mice raised obviously;0.15 mg/kg of MPS could stimulate mice to produce 500 U GM-CSF per 0.1 mL sera,1.0 mg/kg of MPS could make mice induce 850 U GM-CSF per 0.1 mL sera.Analysis indicated that the activity levels of the MPS was the same as Japanese Z-100,and the hemopoietic effects of MPS may be indirect by stimulating monocytes and T lymphacytes indirectly.

Key words: MPS, mouse hemopoietic progenitor(GM-CFU), GM-CSF activity levels of sera

中图分类号:

R392

迟永春;万方;徐梅;陈仁. 分枝杆菌多糖对小鼠造血功能的影响[J]. 首都医科大学学报, 1994, 15(3): 197-199.

Chi Yongchun;Wan Fang;Xu Mei;Chen Ren. Effects of MPS on the Hemopoietic Function of Mice[J]. Journal of Capital Medical University, 1994, 15(3): 197-199.

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