喉良性及恶性病变的Ag－NORs定量研究

首都医科大学学报 ›› 1994, Vol. 15 ›› Issue (3): 209-211.

喉良性及恶性病变的Ag－NORs定量研究

郭秀婵¹, 王卫华¹, 苏鸿禧¹, 卢志达², 王植平²

1. 北京市耳鼻喉科研究所;2. 首都医学院附属北京同仁医院病理科

收稿日期:1993-05-31 修回日期:1900-01-01 出版日期:1994-07-15 发布日期:1994-07-15

A Quantitative Study of Nucleolar Regions in Benign Malignant Lesions of Larynx

Guo Xiuchan¹, Wang Weihua¹, Su Hongxi¹, Lu Zhida², Wang Zhiping²

1. Beijing Institute of Otorhinolaryngology;2. Beijing Tongren Hospital, Capital Institute of Medicine

Received:1993-05-31 Revised:1900-01-01 Online:1994-07-15 Published:1994-07-15

摘要/Abstract

摘要： 对55例喉良性及恶性病变组织进行了Ag-NORs染色.结果表明喉癌组癌细胞内Ag-NORs颗粒形态、大小不等,散布于细胞核内,均值为3.29±0.63;非典型增生组上皮细胞内Ag-NORs颗粒大小不同,部分散在于核内,均值为2.11±0.34; 喉乳头状瘤细胞Ag-NORs颗粒大小均匀,多数位于核仁内,均值为1.72±0.17.经统计学处理,3组间均有显着差异(均P<0.01),提示Ag-NORs计数对喉良、恶性肿瘤的鉴别,检测癌前病变及观察肿瘤生物学行为均有意义.

关键词: 喉鳞状上皮癌, 核仁组成区, 病理学

Abstract: Silver-binding nucleolar organizer regions(Ag-NORs)have been counted in section of routinely processed paraffinembedded tissue blocks.We have examined 55 benign and malignant lesions of larynx by this method.The Ag-NOR counts were 3.29±0.63(n=32)for carcinomas,2.11±0. 34(n=8)for atypical hyperplasia and 1.72 ±0.17(n=14)for papilloma.Carcinomas had significantly higher counts than the other two groups(P<0.01).Between atypical hyperplasia and papilloma groups,the difference of mean Ag-NOR numbers were significant(P<0.01).It may be that the numbers of Ag-NOR reflect cell biological activity or even neoplasia. This method could perhaps be used quantitatively or semiquantitatively to assist in the diagnosis of malignant and benign lesions of larynx or even precancerosis.

Key words: squamous cell carcinoma of larynx, nucleolar organizer regions, pathology

中图分类号:

郭秀婵;王卫华;苏鸿禧;卢志达;王植平. 喉良性及恶性病变的Ag－NORs定量研究[J]. 首都医科大学学报, 1994, 15(3): 209-211.

Guo Xiuchan;Wang Weihua;Su Hongxi;Lu Zhida;Wang Zhiping. A Quantitative Study of Nucleolar Regions in Benign Malignant Lesions of Larynx[J]. Journal of Capital Medical University, 1994, 15(3): 209-211.

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