首都医科大学学报 ›› 1994, Vol. 15 ›› Issue (3): 215-217.

• 论著 • 上一篇    下一篇

分枝杆菌多糖治疗小儿反复呼吸道感染的临床观察

张永珩1, 刘淑玫1, 张盼弟1, 李淑清1, 诸小侬2, 王鸿2, 王津津3   

  1. 1. 首都医学院附属北京同仁医院儿科;2. 北京市耳鼻咽喉科研究所;3. 首都医学院附属北京同仁医院中心实验室
  • 收稿日期:1993-06-15 修回日期:1900-01-01 出版日期:1994-07-15 发布日期:1994-07-15

An Observation of Mycobacterial Polysaccharides(MPS)on Treatment of Repeated Respiratory Tract infection in Children

Zhang Yongheng1, Liu Shumei1, Zhang Pandi1, Li Shuqing1, Wang Jinjin2, Zhu Xiaonong2, Wang Hong3   

  1. 1. Beijing Tongren Hospital, Capital Institute of Medicine;2. Beijing Institute of Otorhinolaryngology
  • Received:1993-06-15 Revised:1900-01-01 Online:1994-07-15 Published:1994-07-15

摘要: 对23例反复呼吸道感染小儿采用分枝杆菌多糖(MPS)系统治疗观察,检测用药前后T细胞亚群CD4、CD8及CD4/CD8之变化,并与健康对照组相比,同时进行临床疗效判断.结果患儿组治疗前CD4及CD4/CD8均较对照组降低.经MPS治疗后两者均明显上升,且与健康对照组无显着差异.临床疗效判断显效和有效22例,无效1例.提示反复呼吸道感染小儿T细胞免疫功能受到抑制,MPS对改善其细胞免疫功能状态有一定作用.

关键词: 反复呼吸道感染, 免疫, T细胞亚群

Abstract: 51 cases of repeated respiratory tract infection patient were treated with MPS.20 cases of normal children were selected as control group.T-cell subgroup(CD)in peripheral blood were examined for the children of 2 groups.The effects of MPS were evaluated on the patients'clinical changes and the results of CD change.The conclusion is as follows:①The levels of CD4 and CD4/CD8 in the patient group were lower than that of the normal children of control group before treatment(P<0.01),indicating that the function of cellular immunity in susceptible children in low. ②Reexamination of CD for 31 patients after treatment with MPS revealed that there is no significant difference for CD3,CD4,CD4/CD8 as compared with control group(P>0.05),indicating that MPS could improve the function for the cellular immunity of the patients. ③Clinically among 51 cases of patient,21 cases were very much improved,indicating MPS is significantly effective in the treatment of RRI and 28 cases were improved,indicating MPS is effective making a total effective rate 96% .

Key words: repeated respiratory tract infection, immunity, T-cell subgroup(CD)

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