苦参乙醇提取物体外抗贾第虫药物作用的观察

首都医科大学学报 ›› 1994, Vol. 15 ›› Issue (4): 261-264.

苦参乙醇提取物体外抗贾第虫药物作用的观察

吴玲清¹, 卢思奇², 王凤芸², 赵玉英³

1. 北京联合大学中医药学院寄生虫学教研室;2. 首都医学院寄生虫学教研室;3. 北京医科大学药学院植化室

收稿日期:1993-08-26 修回日期:1900-01-01 出版日期:1994-10-15 发布日期:1994-10-15

In Vitro Effect of Ethanol Extract of Sophora Flavescens Ait on Giardia Lamblia

Wu Lingqing¹, Lu Siqi², Wang Fengyun², Zhao Yuying³

1. Department of Parasitology, College of Chinese Traditonal Medicine, Beijing Union University;2. Department of Parasitology, Capital Institute of Medicine;3. Department of Plant Chemistry,Pharmocology College, Beijing Medical University

Received:1993-08-26 Revised:1900-01-01 Online:1994-10-15 Published:1994-10-15

摘要/Abstract

摘要： 对苦参乙醇提取物体外抗贾第虫药物作用做了观察.实验结果表明,将此药物与贾第虫滋养体共同培养5h后,导致99%虫体致死的浓度为5g/L,随着药物浓度的降低,致死率相应减少;该药的半数致死浓度为1.5g/L,在此浓度的最短作用时间为3h.对照试验结果显示,在相同时间作用下,阿苯哒唑导致93.8%虫体致死的浓度为0.2g/L.

关键词: 贾第虫, 苦参乙醇提取物, 致死率, 半数致死浓度

Abstract: Ethanol extract of the Sophora flavecens Ait was evaluated in vitro for antigiardia effect.The lethal concentration to 99% of the organism was 5g/L on the 5h after cultivated with the trophozoites of Giardia lamblia. The lethality rates were decreased with the decline of the drug concentrations when cultivated with the parasites at the same period. The half lethal concentration was 1.5g/L and the shortest time at this concentration was 3h. The control test showed that 93.8% Giardia trophozites was killed by albendazole when it' s concentration was at 0.2g/L. The present study may provide an experimental datum for the treatment of giardiasis.

Key words: Giardia lamblia, ethanl extract of Sophora flavescens Ait, lethality rate, half lethal concentration

中图分类号:

R532.17

吴玲清;卢思奇;王凤芸;赵玉英. 苦参乙醇提取物体外抗贾第虫药物作用的观察[J]. 首都医科大学学报, 1994, 15(4): 261-264.

Wu Lingqing;Lu Siqi;Wang Fengyun;Zhao Yuying. In Vitro Effect of Ethanol Extract of Sophora Flavescens Ait on Giardia Lamblia[J]. Journal of Capital Medical University, 1994, 15(4): 261-264.

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[2]	阎歌;卢思奇;王凤芸. 从家兔分离贾第虫并建立纯培养[J]. 首都医科大学学报, 1995, 16(1): 24-26.
[3]	卢思奇;王凤芸;肖祖林. 蓝氏贾第虫福建株的分离与纯培养[J]. 首都医科大学学报, 1994, 15(3): 188-190.
[4]	卢思奇;庞苏红;王凤芸;赵玉英;楼之岑. 苦参体外抗贾第虫药物作用的初步观察[J]. 首都医科大学学报, 1993, 14(2): 99-101.